Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-9-4
pubmed:abstractText
Comparative studies of ethnically diverse human populations, particularly in Africa, are important for reconstructing human evolutionary history and for understanding the genetic basis of phenotypic adaptation and complex disease. African populations are characterized by greater levels of genetic diversity, extensive population substructure, and less linkage disequilibrium (LD) among loci compared to non-African populations. Africans also possess a number of genetic adaptations that have evolved in response to diverse climates and diets, as well as exposure to infectious disease. This review summarizes patterns and the evolutionary origins of genetic diversity present in African populations, as well as their implications for the mapping of complex traits, including disease susceptibility.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1527-8204
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-33
pubmed:dateRevised
2010-12-3
pubmed:meshHeading
pubmed-meshheading:18593304-Acquired Immunodeficiency Syndrome, pubmed-meshheading:18593304-Africa, pubmed-meshheading:18593304-Chromosomes, Human, Y, pubmed-meshheading:18593304-Communicable Diseases, pubmed-meshheading:18593304-DNA, Mitochondrial, pubmed-meshheading:18593304-Diabetes Mellitus, Type 2, pubmed-meshheading:18593304-Diet, pubmed-meshheading:18593304-Disease, pubmed-meshheading:18593304-Evolution, Molecular, pubmed-meshheading:18593304-Female, pubmed-meshheading:18593304-Genetic Variation, pubmed-meshheading:18593304-Genetics, Population, pubmed-meshheading:18593304-Haplotypes, pubmed-meshheading:18593304-Humans, pubmed-meshheading:18593304-Hypertension, pubmed-meshheading:18593304-Lactase, pubmed-meshheading:18593304-Linkage Disequilibrium, pubmed-meshheading:18593304-Malaria, pubmed-meshheading:18593304-Male, pubmed-meshheading:18593304-Obesity, pubmed-meshheading:18593304-Pharmacogenetics, pubmed-meshheading:18593304-Recombination, Genetic, pubmed-meshheading:18593304-Selection, Genetic, pubmed-meshheading:18593304-Tuberculosis, Pulmonary
pubmed:year
2008
pubmed:articleTitle
African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.
pubmed:affiliation
Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA. mcam@mail.med.upenn.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural