Linked Life Data

18592597

Source:http://linkedlifedata.com/resource/pubmed/id/18592597

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2008-7-1
pubmed:abstractText
The stereoselective reduction of ethyl acetoacetate to (+)-(S)-ethyl 3-hydroxybutyrate catalyzed by Saccharomyces cerevisiae was optimized by means of chemometric methods. The quantitative effects of temperature, time of incubation, and concentrations of yeast and substrate on the optical purity and on the percent of reduced substrate were investigated using a factorial design at two levels. This approach gave information about the chemical behavior of the catalyst. The variability of the two responses was expressed by means of their corresponding response surfaces. Use of desirability functions allowed the overall optimization of the process, also taking into account the importance of economic factors. The investigation showed that it is possible to reduce the substrate completely obtaining (+)-(S)-ethyl 3-hydroxybutyrate with percent of enantiomeric excess>98% and, at the same time, to operate in more convenient experimental conditions than those previously reported.
pubmed:language
eng
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Apr
pubmed:issn
0006-3592
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
928-34
pubmed:year
1990
pubmed:articleTitle
Chemometric optimization of an asymmetric reduction catalyzed by baker's yeast.
pubmed:affiliation
Istituto di Chimica Farmaceutica, Università di Trieste, 34127 Trieste, Italy.
pubmed:publicationType
Journal Article