Linked Life Data

18591476

Source:http://linkedlifedata.com/resource/pubmed/id/18591476

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-7-1
pubmed:abstractText
Biased competition models of selective attention suggest that attentional competition is influenced both by bottom-up sensory mechanisms sensitive to stimulus salience and top-down control mechanisms that support the processing of task-relevant stimuli. This provides a framework for investigating the neural mechanisms underlying selective attention to threat. Both subcortical regions implicated in threat detection--specifically the amygdala--and prefrontal cortical regions implicated in top-down attentional control are activated in response to task-irrelevant threat stimuli. A number of questions including the automaticity of the amygdala response to threat distractors, the modulation by anxiety of the amygdala and prefrontal response to these stimuli, and the impact of genetic and environmental factors upon this circuitry are addressed. The empirical literature is considered in the context of theoretical accounts of the neural substrate of selective attention and conscious awareness. It is suggested that the neural activity provoked by a given visual stimulus is influenced by factors impacting upon the strength of the bottom-up trace (e.g., presentation time, backward masking), stimulus salience (including threat relatedness), competition with other visual stimuli for perceptual processing resources, and the augmentation of the stimulus trace by allocation of top-down attentional resources. Individual differences in trait and state anxiety, and in genetic makeup, are thought to modulate the influence of stimulus valence and top-down attention through their impact upon amygdala and prefrontal function.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1129
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-52
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Neural mechanisms underlying selective attention to threat.
pubmed:affiliation
Behavioural and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB23EB, UK. sb445@cam.ac.uk
pubmed:publicationType
Journal Article, Review