18591271

Source:http://linkedlifedata.com/resource/pubmed/id/18591271

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0003232, umls-concept:C0017262, umls-concept:C0038172, umls-concept:C0086045, umls-concept:C1280500, umls-concept:C1333237
pubmed:issue	9
pubmed:dateCreated	2008-8-26
pubmed:abstractText	Reporter clones of Staphylococcus aureus with different SOS response- and DNA repair-associated promoter-lux gene fusion constructs were constructed to study the effects of sub-MICs of antibiotics on the transcription of the SOS and methyl mismatch repair (MMR) genes. Fluoroquinolones (FQs) upmodulated both the SOS and the MMR genes. The patterns of antibiotic-induced transcriptional modulation were altered in FQ-resistant mutants.
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0315061
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents, http://linkedlifedata.com/resource/pubmed/chemical/Arabidopsis Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Fluoroquinolones, http://linkedlifedata.com/resource/pubmed/chemical/Lux Arrhythmo protein, Arabidopsis, http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1098-6596
pubmed:author	pubmed-author:DaviesJulianJ, pubmed-author:MesakLili RosanaLR, pubmed-author:MiaoVivianV
pubmed:issnType	Electronic
pubmed:volume	52
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3394-7
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:18591271-Anti-Bacterial Agents, pubmed-meshheading:18591271-Arabidopsis Proteins, pubmed-meshheading:18591271-Bacterial Proteins, pubmed-meshheading:18591271-DNA Mismatch Repair, pubmed-meshheading:18591271-DNA Repair, pubmed-meshheading:18591271-Drug Resistance, Bacterial, pubmed-meshheading:18591271-Fluoroquinolones, pubmed-meshheading:18591271-Gene Expression Regulation, Bacterial, pubmed-meshheading:18591271-Humans, pubmed-meshheading:18591271-Microbial Sensitivity Tests, pubmed-meshheading:18591271-Promoter Regions, Genetic, pubmed-meshheading:18591271-Recombinant Fusion Proteins, pubmed-meshheading:18591271-SOS Response (Genetics), pubmed-meshheading:18591271-Staphylococcus aureus, pubmed-meshheading:18591271-Transcription Factors
pubmed:year	2008
pubmed:articleTitle	Effects of subinhibitory concentrations of antibiotics on SOS and DNA repair gene expression in Staphylococcus aureus.
pubmed:affiliation	Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada. mesak@interchange.ubc.ca
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't