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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-8-19
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pubmed:abstractText |
The mechanism by which anaesthetic agents produce general anaesthesia is not yet fully understood. Retraction of neurites is an important function of individual neurones and neural plexuses during normal and pathological conditions, and it has been shown that such a retraction pathway exists in developing and mature neurones. We hypothesized that propofol decreases neuronal activity by causing retraction of neuronal neurites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1471-6771
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
374-9
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pubmed:meshHeading |
pubmed-meshheading:18587139-Anesthetics, Intravenous,
pubmed-meshheading:18587139-Animals,
pubmed-meshheading:18587139-Bicuculline,
pubmed-meshheading:18587139-Cells, Cultured,
pubmed-meshheading:18587139-Cerebral Cortex,
pubmed-meshheading:18587139-Dose-Response Relationship, Drug,
pubmed-meshheading:18587139-GABA Antagonists,
pubmed-meshheading:18587139-Heterocyclic Compounds with 4 or More Rings,
pubmed-meshheading:18587139-Neurites,
pubmed-meshheading:18587139-Phalloidine,
pubmed-meshheading:18587139-Propofol,
pubmed-meshheading:18587139-Rats,
pubmed-meshheading:18587139-Rats, Sprague-Dawley
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pubmed:year |
2008
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pubmed:articleTitle |
Propofol causes neurite retraction in neurones.
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pubmed:affiliation |
Department of Anaesthesiology, Faculty of Health Sciences, Linköping University, 58185 Linköping, Sweden. dean.turina@lio.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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