18586294

Source:http://linkedlifedata.com/resource/pubmed/id/18586294

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0026626, umls-concept:C0085732, umls-concept:C0443288, umls-concept:C0596988, umls-concept:C1311670, umls-concept:C1514562, umls-concept:C1517378, umls-concept:C1880389, umls-concept:C1883204, umls-concept:C1883221
pubmed:issue	2
pubmed:dateCreated	2008-8-18
pubmed:abstractText	Human TRIM5alpha restricts N-tropic murine leukemia virus (N-MLV) but not B-tropic MLV (B-MLV) infection. Here we study B30.2/SPRY domain mutants of human TRIM5alpha that acquire the ability to inhibit B-MLV infection prior to reverse transcription without losing the ability to restrict N-MLV infection. Remarkably, these mutants gain the ability to decrease the amount of particulate B-MLV capsids in the cytosol of infected cells. In addition, these mutants gain the ability to restrict SIV(mac) and HIV-2 infection. B-MLV and SIV(mac) infections were blocked by the mutant TRIM5alpha proteins prior to reverse transcription. Thus, the range of retroviruses restricted by human TRIM5alpha can be increased by changes in the B30.2/SPRY domain, which also result in the ability to cause premature uncoating of the restricted retroviral capsid.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/AI063987, http://linkedlifedata.com/resource/pubmed/grant/AI076094, http://linkedlifedata.com/resource/pubmed/grant/AI60354, http://linkedlifedata.com/resource/pubmed/grant/R01 AI063987-04, http://linkedlifedata.com/resource/pubmed/grant/R21 AI076094-01
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-10559316, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-10906195, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-11027299, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-11238863, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-12154227, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-12368468, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-12388705, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-12438612, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-14985764, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15249685, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15249687, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15280539, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15649369, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15689398, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15709033, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15767395, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-15857996, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16140735, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16540544, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16648264, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16650449, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16699044, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16809279, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16912305, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-16973579, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-17135314, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-17316734, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-17626085, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-17920096, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-18166079, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-9557668, http://linkedlifedata.com/resource/pubmed/commentcorrection/18586294-9930301
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0110674
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Green Fluorescent Proteins, http://linkedlifedata.com/resource/pubmed/chemical/TRIM5 protein, human
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1096-0341
pubmed:author	pubmed-author:Diaz-GrifferoFelipeF, pubmed-author:HannaRobertR, pubmed-author:MaillardPierre VPV, pubmed-author:McGee-EstradaKathleenK, pubmed-author:PerronMichelM, pubmed-author:SodroskiJosephJ, pubmed-author:TronoDidierD
pubmed:issnType	Electronic
pubmed:day	1
pubmed:volume	378
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	233-42
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:18586294-Capsid, pubmed-meshheading:18586294-Carrier Proteins, pubmed-meshheading:18586294-Cell Line, pubmed-meshheading:18586294-Cytoplasm, pubmed-meshheading:18586294-Genes, Reporter, pubmed-meshheading:18586294-Green Fluorescent Proteins, pubmed-meshheading:18586294-HIV-2, pubmed-meshheading:18586294-Humans, pubmed-meshheading:18586294-Leukemia Virus, Murine, pubmed-meshheading:18586294-Mutation, Missense, pubmed-meshheading:18586294-Protein Structure, Tertiary, pubmed-meshheading:18586294-Simian immunodeficiency virus
pubmed:year	2008
pubmed:articleTitle	A human TRIM5alpha B30.2/SPRY domain mutant gains the ability to restrict and prematurely uncoat B-tropic murine leukemia virus.
pubmed:affiliation	Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Department of Pathology, Division of AIDS, Harvard Medical School, Boston, MA 02115, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural