| pubmed-article:18586005 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0024375 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C1704256 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0677626 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0007608 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0033374 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C1415793 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0031669 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:18586005 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:18586005 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:18586005 | pubmed:dateCreated | 2008-7-28 | lld:pubmed |
| pubmed-article:18586005 | pubmed:abstractText | Transforming growth factor-beta1 (TGF-beta1) is a multi-functional cytokine involved in the regulation of cell proliferation, differentiation and extracellular matrix formation. In search for novel genes mediating the TGF-beta1 function at downstream signaling, we performed a cDNA microarray analysis and identified 60 genes whose expression is regulated by TGF-beta1 in the liver cancer cell line PLC/PRF/5. Among them, we report here lysyl oxidase like 4 (LOXL4) as a novel target of TGF-beta1 signaling, and provide experimental evidence for its expression regulation and function. LOXL4 was found to be the only member of LOX family whose expression is induced by TGF-beta1 in hepatoma cells. Deletion mapping of the LOXL4 promoter indicated that the TGF-beta1 regulation of LOXL4 expression is mediated through the binding of AP1 transcription factor to a conserved region of the promoter. This was confirmed by the chromatin immunoprecipitation assay that captured c-Fos-bound chromatin from TGF-beta1-treated cells. Forced expression of LOXL4 in PLC/PRF/5 cells resulted in inhibition of cell motility through Matrigel in the presence of TGF-beta1 treatment. In parallel, LOXL4 suppressed the expression of laminins and alpha3 integrin and the activity of MMP2. These results suggest that LOXL4 may function as a negative feedback regulator of TGF-beta1 in cell invasion by inhibiting the metabolism of extracellular matrix (ECM) components. | lld:pubmed |
| pubmed-article:18586005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:18586005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:18586005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:18586005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:18586005 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:18586005 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:KimDong MinDM | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:KimSoo JungSJ | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:LeeJung JuJJ | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:ParkKyung... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:KimDong... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:MinSang... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:YeomYoung... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:LeeDong... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:YangSuk-JinSJ | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:MyungPyung... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:BaeEun MiEM | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:KangDong... | lld:pubmed |
| pubmed-article:18586005 | pubmed:author | pubmed-author:SangByung... | lld:pubmed |
| pubmed-article:18586005 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:18586005 | pubmed:day | 5 | lld:pubmed |
| pubmed-article:18586005 | pubmed:volume | 373 | lld:pubmed |
| pubmed-article:18586005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:18586005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:18586005 | pubmed:pagination | 521-7 | lld:pubmed |
| pubmed-article:18586005 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:meshHeading | pubmed-meshheading:18586005... | lld:pubmed |
| pubmed-article:18586005 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:18586005 | pubmed:articleTitle | Lysyl oxidase like 4, a novel target gene of TGF-beta1 signaling, can negatively regulate TGF-beta1-induced cell motility in PLC/PRF/5 hepatoma cells. | lld:pubmed |
| pubmed-article:18586005 | pubmed:affiliation | Medical Genomics Research Center, KRIBB, P.O. Box 115, Yusong, Daejeon 305-806, Republic of Korea. | lld:pubmed |
| pubmed-article:18586005 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:18586005 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:84171 | entrezgene:pubmed | pubmed-article:18586005 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:18586005 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:18586005 | lld:pubmed |
