Linked Life Data

18585948

Source:http://linkedlifedata.com/resource/pubmed/id/18585948

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2008-7-21
pubmed:abstractText
Engrailed genes are homeodomain-containing transcription factors necessary for the development and maintenance of mesencephalic dopaminergic neurons. Deletion in the Engrailed genes has been shown to affect the survival of mesencephalic dopaminergic neurons both during development and in the adult. Here we describe for the first time a significant reduction in striatal dopamine levels in En1+/-;En2+/- mice compared with their En2+/- littermates, accompanied by a modest reduction in the number of nigral DA neurons. Our results strengthen previous evidence indicating Engrailed genes as survival factors for mature dopaminergic neurons. Furthermore, our data suggest a role for these transcription factors in the maintenance of synaptic dopaminergic neurotransmission in adult neurons.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1353-8020
pubmed:author
pubmed:issnType
Print
pubmed:volume
14 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S103-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Characterization of the Engrailed mutant mice as experimental models for Parkinson's disease.
pubmed:affiliation
Department of Neuroscience, University of Pisa School of Medicine, Via Roma 55, Pisa, Italy. p.sgado@meyer.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't