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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
15
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pubmed:dateCreated |
2008-8-11
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pubmed:abstractText |
Several N(1)-substituted 1,3-dihydro-2H-benzimidazol-2-ones were synthesized and evaluated as anti-HIV agents. Some of them proved to be highly effective in inhibiting HIV-1 replication at nanomolar concentration as potent non-nucleoside HIV-1 RT inhibitors (NNRTIs) with low cytotoxicity. SAR studies highlighted that the nature of the substituents at N(1) and on the benzene ring of benzimidazolone moiety significantly influenced the anti-HIV activity of this class of potent antiretroviral agents.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:BarrecaMaria LetiziaML,
pubmed-author:ChimirriAlbaA,
pubmed-author:De ClercqErikE,
pubmed-author:De LucaLauraL,
pubmed-author:FerroStefaniaS,
pubmed-author:IraciNunzioN,
pubmed-author:LogotetaPatriziaP,
pubmed-author:MagaGiovanniG,
pubmed-author:MonforteAnna-MariaAM,
pubmed-author:PannecouqueChristopheC,
pubmed-author:RaoAngelaA
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7429-35
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pubmed:meshHeading |
pubmed-meshheading:18585918-Anti-HIV Agents,
pubmed-meshheading:18585918-Benzimidazoles,
pubmed-meshheading:18585918-Cell Line,
pubmed-meshheading:18585918-HIV-1,
pubmed-meshheading:18585918-Humans,
pubmed-meshheading:18585918-Models, Molecular,
pubmed-meshheading:18585918-Molecular Structure,
pubmed-meshheading:18585918-Reverse Transcriptase Inhibitors,
pubmed-meshheading:18585918-Structure-Activity Relationship,
pubmed-meshheading:18585918-Virus Replication
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pubmed:year |
2008
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pubmed:articleTitle |
Novel N1-substituted 1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside reverse transcriptase inhibitors.
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pubmed:affiliation |
Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy. ammonforte@pharma.unime.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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