|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0018787,
umls-concept:C0031809,
umls-concept:C0036043,
umls-concept:C0043457,
umls-concept:C0183185,
umls-concept:C0234621,
umls-concept:C0699819,
umls-concept:C0920472,
umls-concept:C1510438,
umls-concept:C1527178,
umls-concept:C1705938
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|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2008-9-1
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|
pubmed:abstractText |
Safety pharmacology is integral to the non-clinical safety assessment of new chemical entities prior to first administration to humans. The zebrafish is a well established model organism that has been shown to be relevant to the study of human diseases. The potential role of zebrafish in safety pharmacology was evaluated using reference compounds in three models assessing cardiac, visual and intestinal function.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1873-488X
|
|
pubmed:author |
pubmed-author:AldertonWendyW,
pubmed-author:BerghmansStéphaneS,
pubmed-author:ButlerPaulP,
pubmed-author:FlemingAngeleenA,
pubmed-author:GardnerIainI,
pubmed-author:GolderZoeZ,
pubmed-author:GoldsmithPaulP,
pubmed-author:KimberGillianG,
pubmed-author:RichardsFrances MFM,
pubmed-author:RoachAlanA,
pubmed-author:WaldronGarethG
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|
pubmed:issnType |
Electronic
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|
pubmed:volume |
58
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
59-68
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:18585469-Animals,
pubmed-meshheading:18585469-Drug Evaluation, Preclinical,
pubmed-meshheading:18585469-Gastrointestinal Tract,
pubmed-meshheading:18585469-Heart,
pubmed-meshheading:18585469-Humans,
pubmed-meshheading:18585469-Larva,
pubmed-meshheading:18585469-Models, Animal,
pubmed-meshheading:18585469-Pharmaceutical Preparations,
pubmed-meshheading:18585469-Species Specificity,
pubmed-meshheading:18585469-Time Factors,
pubmed-meshheading:18585469-Toxicity Tests,
pubmed-meshheading:18585469-Vision, Ocular,
pubmed-meshheading:18585469-Zebrafish
|
|
pubmed:articleTitle |
Zebrafish based assays for the assessment of cardiac, visual and gut function--potential safety screens for early drug discovery.
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|
pubmed:affiliation |
Summit (Cambridge) Ltd., Cambridge, United Kingdom.
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pubmed:publicationType |
Journal Article,
Comparative Study
|
