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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2008-9-5
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pubmed:abstractText |
Free fatty acids (FFAs) acutely stimulate but chronically impair glucose-stimulated insulin secretion from beta-cells. The G protein-coupled transmembrane receptor 40 (GPR40) mediates both acute and chronic effects of FFAs on insulin secretion and plays a role in glucose homeostasis. Limited information is available on the effect of GPR40 genetic abnormalities on insulin secretion and metabolic regulation in human subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-972X
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pubmed:author |
pubmed-author:BarattaRobertoR,
pubmed-author:De StefaniDiegoD,
pubmed-author:FarinaMaria GraziaMG,
pubmed-author:FederspilGiovanniG,
pubmed-author:FrittittaLuciaL,
pubmed-author:GranzottoMarnieM,
pubmed-author:MilanGabriellaG,
pubmed-author:NigroAngelaA,
pubmed-author:PilonCatiaC,
pubmed-author:RizzutoRosarioR,
pubmed-author:RossatoMarcoM,
pubmed-author:TrevellinElisabettaE,
pubmed-author:VettorRobertoR,
pubmed-author:VigneriRiccardoR,
pubmed-author:VitielloLiberoL
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3541-50
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18583466-Adult,
pubmed-meshheading:18583466-Calcium,
pubmed-meshheading:18583466-DNA Mutational Analysis,
pubmed-meshheading:18583466-Female,
pubmed-meshheading:18583466-Gene Frequency,
pubmed-meshheading:18583466-Genetic Linkage,
pubmed-meshheading:18583466-Genotype,
pubmed-meshheading:18583466-Glucose Tolerance Test,
pubmed-meshheading:18583466-HeLa Cells,
pubmed-meshheading:18583466-Humans,
pubmed-meshheading:18583466-Insulin,
pubmed-meshheading:18583466-Insulin-Secreting Cells,
pubmed-meshheading:18583466-Intracellular Fluid,
pubmed-meshheading:18583466-Male,
pubmed-meshheading:18583466-Middle Aged,
pubmed-meshheading:18583466-Models, Biological,
pubmed-meshheading:18583466-Mutation, Missense,
pubmed-meshheading:18583466-Obesity,
pubmed-meshheading:18583466-Receptors, G-Protein-Coupled,
pubmed-meshheading:18583466-Transfection
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pubmed:year |
2008
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pubmed:articleTitle |
Loss-of-function mutation of the GPR40 gene associates with abnormal stimulated insulin secretion by acting on intracellular calcium mobilization.
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pubmed:affiliation |
Endocrine-Metabolic Laboratory, Internal Medicine, Department of Medical and Surgical Sciences, University of Padova, via Ospedale, 105, I-35128 Padova, Italy. roberto.vettor@unipd.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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