Linked Life Data

18583109

Source:http://linkedlifedata.com/resource/pubmed/id/18583109

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-7-22
pubmed:abstractText
According to the concept of green chemistry and sustainable development, a new biodegradable copolymer comprised of hydrophobic poly(l-lactide) (PLLA) segments and hydrophilic cellulose segment (cellulose-g-PLLA) was designed and synthesized. The structure of the copolymer was characterized by (1)H NMR, FT-IR, (13)C NMR, DSC and WAXD. The cytotoxicity study shows that cellulose-g-PLLA exhibits good biocompatibility. The copolymer can self-assemble into micelles in water with the hydrophobic PLLA segments at the cores of micelles and the hydrophilic cellulose segments as the outer shells. Transmission electron microscopy (TEM) shows that the micelles exhibit nanospheric morphology within a size range of 30-80nm. The drug loaded micelles formed by the copolymer in aqueous media show sustained drug release which indicates their potential applicability in drug carrier.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0927-7765
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-33
pubmed:dateRevised
2009-10-16
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
The synthesis of biodegradable graft copolymer cellulose-graft-poly(L-lactide) and the study of its controlled drug release.
pubmed:affiliation
Department of Polymer Science, Key Laboratory of Biomedical Polymers, Wuhan University, Ministry of Education, Wuhan 430072, People's Republic of China.
pubmed:publicationType
Journal Article