Source:http://linkedlifedata.com/resource/pubmed/id/18581044
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
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pubmed:dateCreated |
2008-7-31
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pubmed:abstractText |
The absorption efficiency of cholesterol is closely correlated to dietary phytosterol content and determined by genetic factors. The ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 act as a sterol efflux pump to regulate the absorption of cholesterol and phytosterol. The levels of cholesterol and phytosterol associated with a Chinese diet are very different from those associated with a Western diet. This study aims to explore the association between serum total cholesterol/LDL-C levels and ABCG5/ABCG8 polymorphisms in a Taiwanese population consuming an ordinary Chinese diet. A total of 1,046 subjects (894 men and 152 women) were recruited in a hospital-based health check-up center in Kaohsiung Medical University Hospital. Five nonsynonymous polymorphisms of Q604E (ABCG5), D19H, C54Y, T400 K and A632 V (ABCG8) were analyzed by TaqMan genotyping assay. Analysis showed that the D19H polymorphism of the ABCG8 gene was significantly associated with serum total cholesterol, LDL-C levels and HOMA-IR index. Adjusting for sex and age, subjects with the D19H (GC) genotype were significantly associated with a threefold higher risk of high cholesterol and LDL-C levels than subjects with D19 (GG). These results suggest that the D19H polymorphism of ABCG8 could be considered a susceptible gene marker indicating an increased likelihood of developing high cholesterol and LDL-C levels in Taiwanese consuming an ordinary Chinese diet. It is supposed that the coexistence of higher insulin resistance and hypercholesterolemia for carriers of the D19H polymorphism may result in a greater risk of cardiovascular disease.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCG8 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ATP-Binding Cassette Transporters,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Histidine
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pubmed:status |
MEDLINE
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pubmed:issn |
1434-5161
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
53
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
757-63
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pubmed:meshHeading |
pubmed-meshheading:18581044-ATP-Binding Cassette Transporters,
pubmed-meshheading:18581044-Adult,
pubmed-meshheading:18581044-Aged,
pubmed-meshheading:18581044-Amino Acid Substitution,
pubmed-meshheading:18581044-Aspartic Acid,
pubmed-meshheading:18581044-Cholesterol, LDL,
pubmed-meshheading:18581044-Female,
pubmed-meshheading:18581044-Histidine,
pubmed-meshheading:18581044-Humans,
pubmed-meshheading:18581044-Hypercholesterolemia,
pubmed-meshheading:18581044-Insulin Resistance,
pubmed-meshheading:18581044-Male,
pubmed-meshheading:18581044-Middle Aged,
pubmed-meshheading:18581044-Polymorphism, Genetic,
pubmed-meshheading:18581044-Risk Factors
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pubmed:year |
2008
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pubmed:articleTitle |
Significant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance.
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pubmed:affiliation |
Division of Cardiology and General Medicine, Chi-Mei Medical Center, Chung Hwa University of Medical Technology, Tainan, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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