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18579373
Source:
http://linkedlifedata.com/resource/pubmed/id/18579373
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Statements in which the resource exists as a subject.
Predicate
Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0033384
,
umls-concept:C0205314
,
umls-concept:C0220781
,
umls-concept:C0220825
,
umls-concept:C0243077
,
umls-concept:C0268563
,
umls-concept:C0679622
,
umls-concept:C0870071
,
umls-concept:C1880355
,
umls-concept:C1883254
pubmed:issue
14
pubmed:dateCreated
2008-7-21
pubmed:abstractText
Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Hypoxia-Inducible Factor 1, alpha...
,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1464-3405
pubmed:author
pubmed-author:AllenJennifer RJR
,
pubmed-author:BürliRoland WRW
,
pubmed-author:BiddlecomeGloriaG
,
pubmed-author:BiswasKaustavK
,
pubmed-author:ChangCatherineC
,
pubmed-author:DaoJennifer HJH
,
pubmed-author:FrohnMichael JMJ
,
pubmed-author:HungateRandall WRW
,
pubmed-author:PeterkinTanya A NTA
,
pubmed-author:RogersNormaN
,
pubmed-author:TagariPhilipP
,
pubmed-author:TegleyChristopher MCM
,
pubmed-author:VeithHenrikeH
,
pubmed-author:ViswanadhanVellarkad NVN
,
pubmed-author:YoderSean CSC
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3925-8
pubmed:meshHeading
pubmed-meshheading:18579373-Chemistry, Pharmaceutical
,
pubmed-meshheading:18579373-Diabetes Mellitus
,
pubmed-meshheading:18579373-Drug Design
,
pubmed-meshheading:18579373-Drug Evaluation, Preclinical
,
pubmed-meshheading:18579373-Erythrocytes
,
pubmed-meshheading:18579373-Humans
,
pubmed-meshheading:18579373-Hypoxia-Inducible Factor 1, alpha Subunit
,
pubmed-meshheading:18579373-Inhibitory Concentration 50
,
pubmed-meshheading:18579373-Models, Chemical
,
pubmed-meshheading:18579373-Models, Molecular
,
pubmed-meshheading:18579373-Myocardial Infarction
,
pubmed-meshheading:18579373-Peripheral Vascular Diseases
,
pubmed-meshheading:18579373-Stroke
,
pubmed-meshheading:18579373-Structure-Activity Relationship
,
pubmed-meshheading:18579373-Thiazoles
pubmed:year
2008
pubmed:articleTitle
Discovery of novel hydroxy-thiazoles as HIF-alpha prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation.
pubmed:affiliation
Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. ctegley@amgen.com
pubmed:publicationType
Journal Article