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pubmed-article:18576360pubmed:abstractTextTo determine whether genetic variants of the PTPN22 gene, including the R620W (1858C>T) missense single-nucleotide polymorphism (SNP), are associated with systemic sclerosis (SSc). Since PTPN22 is involved in multiple autoimmune diseases, we also examined the occurrence of a concomitant autoimmune disease. We then conducted a meta-analysis of the most recent studies of SSc in order to verify the association or lack of association between the PTPN22 1858C>T variant and SSc.lld:pubmed
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pubmed-article:18576360pubmed:articleTitleThe PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis.lld:pubmed
pubmed-article:18576360pubmed:affiliationUniversité Paris 7, Paris, France. philippe.dieude@bch.aphp.frlld:pubmed
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