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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-15
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pubmed:abstractText |
CCR2 is a chemokine receptor expressed by monocytes, macrophages, and a subset of T cells. Its ligand, CCL2 (monocyte chemotactic protein 1), is abundantly present in the synovium of patients with rheumatoid arthritis (RA). Blocking CCR2 prevents CCL2-mediated chemotaxis in vitro and modulates arthritis in animal models of RA. In this study we examined the effects of CCR2 blockade on synovial inflammation in RA.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:BaetenDominiqueD,
pubmed-author:DinantHuib JHJ,
pubmed-author:GerlagDaniëlle MDM,
pubmed-author:JacobsonEric WEW,
pubmed-author:KlareskogLL,
pubmed-author:LeeYihY,
pubmed-author:LopatinskayaLubaL,
pubmed-author:ParrotPP,
pubmed-author:SmithM DMD,
pubmed-author:VergunstClarissa ECE,
pubmed-author:WyantTimothyT,
pubmed-author:van den BoschFF
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1931-9
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pubmed:meshHeading |
pubmed-meshheading:18576354-Adult,
pubmed-meshheading:18576354-Antibodies, Monoclonal,
pubmed-meshheading:18576354-Arthritis, Rheumatoid,
pubmed-meshheading:18576354-Biological Markers,
pubmed-meshheading:18576354-Chemokine CCL2,
pubmed-meshheading:18576354-Double-Blind Method,
pubmed-meshheading:18576354-Female,
pubmed-meshheading:18576354-Gene Expression,
pubmed-meshheading:18576354-Humans,
pubmed-meshheading:18576354-Male,
pubmed-meshheading:18576354-Middle Aged,
pubmed-meshheading:18576354-Receptors, CCR2,
pubmed-meshheading:18576354-Synovial Membrane
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pubmed:year |
2008
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pubmed:articleTitle |
Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trial.
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pubmed:affiliation |
Academic Medical Center, and University of Amsterdam, Amsterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II
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