Source:http://linkedlifedata.com/resource/pubmed/id/18576208
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2008-6-25
|
| pubmed:abstractText |
A less well-known feature of Parkinson disease is that up to 40% of patients experience distinct sensory disturbances, including hyperalgesia and chronic pain. There is a limited understanding of the neural mechanisms that generate these symptoms, however. This study explores the patterns of Fos expression (a well-known marker for changes in cell activity) in the spinal cord and periaqueductal grey matter (PaG), two major sensory (nociceptive) centers, of hemiParkinsonian rats. The medial forebrain bundle (mfb; major tract carrying dopaminergic nigrostriatal axons) was injected with either 6OHDA or saline (controls). A week later, some rats were subjected to mechanical stimulation (pinching) of the hindpaw for 2 h, whereas others received no stimulation. Thereafter, brains were processed using routine tyrosine hydroxylase (marker for dopaminergic cells) or Fos immunocytochemistry. In the PaG, there were many more Fos(+) cells in the 6OHDA-lesioned than in the Control group, in both the stimulation and, in particular, the non-stimulation cases. In the spinal cord, there were also more Fos(+) cells in the 6OHDA-lesioned than in the Control group, but in the stimulation cases only. Overall, the results show distinct changes in Fos expression in the spinal cord and PaG of 6OHDA-lesioned rats, suggesting a substrate for some of the abnormal sensory (nociceptive) circuits that may be evident in parkinsonian cases.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
|
| pubmed:issn |
1563-5279
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
118
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1053-79
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| pubmed:meshHeading |
pubmed-meshheading:18576208-Animals,
pubmed-meshheading:18576208-Disease Models, Animal,
pubmed-meshheading:18576208-Functional Laterality,
pubmed-meshheading:18576208-Immunohistochemistry,
pubmed-meshheading:18576208-Lumbar Vertebrae,
pubmed-meshheading:18576208-Male,
pubmed-meshheading:18576208-Neural Pathways,
pubmed-meshheading:18576208-Neurons,
pubmed-meshheading:18576208-Nociceptors,
pubmed-meshheading:18576208-Oxidopamine,
pubmed-meshheading:18576208-Parkinsonian Disorders,
pubmed-meshheading:18576208-Periaqueductal Gray,
pubmed-meshheading:18576208-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:18576208-Rats,
pubmed-meshheading:18576208-Rats, Sprague-Dawley,
pubmed-meshheading:18576208-Sensation Disorders,
pubmed-meshheading:18576208-Spinal Cord,
pubmed-meshheading:18576208-Substantia Nigra,
pubmed-meshheading:18576208-Tissue Distribution,
pubmed-meshheading:18576208-Tyrosine 3-Monooxygenase
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Patterns of FOS expression in the spinal cord and periaqueductal grey matter of 6OHDA-lesioned rats.
|
| pubmed:affiliation |
Department Anatomy and Histology, University of Sydney, Sydney, Australia.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|