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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2008-6-25
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pubmed:abstractText |
Francisella tularensis is a gram-negative coccobacillus that causes the febrile illness tularemia. Subspecies that are pathogenic for humans include those comprising the type A (subspecies tularensis) or type B (subspecies holarctica) biovars. An attenuated live vaccine strain (LVS) developed from a type B isolate has previously been used to vaccinate at-risk individuals, but offers limited protection against high dose (>1000 CFUs) challenge with type A strains delivered by the respiratory route. Due to differences between type A and type B F. tularensis strains at the genetic level, it has been speculated that utilization of an attenuated type A strain as a live vaccine might offer better protection against homologous respiratory challenge compared with LVS. Here, we report the construction and characterization of an unmarked Delta purMCD mutant in the highly virulent type A strain Schu S4.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-12675294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-12732472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-12922099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-13627717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-13746667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-13746668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-14801354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-15574954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-15845466,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-16299332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-16350172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-16373510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-16476789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-16790773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-16861631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-17074846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-17074911,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-17088343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-17316369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-17582573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-1763061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-17662071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-18015689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18575611-5917334
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e2487
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18575611-Administration, Intranasal,
pubmed-meshheading:18575611-Animals,
pubmed-meshheading:18575611-Bacterial Vaccines,
pubmed-meshheading:18575611-Cell Line,
pubmed-meshheading:18575611-Francisella tularensis,
pubmed-meshheading:18575611-Humans,
pubmed-meshheading:18575611-Lung,
pubmed-meshheading:18575611-Macrophages,
pubmed-meshheading:18575611-Mice,
pubmed-meshheading:18575611-Mutation,
pubmed-meshheading:18575611-Purines,
pubmed-meshheading:18575611-Virulence
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pubmed:year |
2008
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pubmed:articleTitle |
A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics and Center for Biopreparedness and Infectious Diseases, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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