Linked Life Data

18573792

Source:http://linkedlifedata.com/resource/pubmed/id/18573792

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-6-24
pubmed:abstractText
Onychomatricoma is a rare nail tumor with a distinctive architecture. Proximally, there are serum-filled invaginations of nail matrix epithelium into the stroma, and distally, dermal protrusions perforate the nail plate. Because other matrical tumors of follicular and odontogenic origin express nuclear beta-catenin, we examined the expression of cadherin/catenin proteins in this onychomatricoma case. The patient presented with a toenail yellow streak, and the biopsy revealed an onychomatricoma. E-cadherin and beta-catenin were at the cell membrane in the epithelial invaginations. P-cadherin was restricted to basal cells. In contrast to other matrical tumors, nuclear beta-catenin was not present. These results suggest that onychomatricoma may lack the transcriptional activating role of beta-catenin that characterizes follicular and odontogenic matrical tumors. This is the first report on the expression of cadherin/ catenin cell-cell adhesion proteins in this rare nail tumor.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1066-8969
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
349-53
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Expression of cadherin/catenin cell--cell adhesion molecules in a onychomatricoma.
pubmed:affiliation
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
pubmed:publicationType
Journal Article, Case Reports