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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-6-24
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pubmed:abstractText |
Calcific aortic stenosis may be an inflammatory disease with active bone formation in the valve leaflets rather than a disease of passive calcium deposition. Epidemiologic data demonstrating correlation of poor dental hygiene to atherosclerotic pathologies suggests that circulating bacterial products could be involved in the pathogenesis of aortic valve stenosis. We hypothesized that lipopolysaccharide (LPS) stimulation of human aortic valve interstitial cells (HAVICs) would induce inflammatory and osteogenic gene expression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1552-6259
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-6
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pubmed:meshHeading |
pubmed-meshheading:18573401-Analysis of Variance,
pubmed-meshheading:18573401-Aortic Valve,
pubmed-meshheading:18573401-Cells, Cultured,
pubmed-meshheading:18573401-Chemokines,
pubmed-meshheading:18573401-Confidence Intervals,
pubmed-meshheading:18573401-Cytokines,
pubmed-meshheading:18573401-Gene Expression Regulation,
pubmed-meshheading:18573401-Humans,
pubmed-meshheading:18573401-Inflammation Mediators,
pubmed-meshheading:18573401-Interleukin-6,
pubmed-meshheading:18573401-Interleukin-8,
pubmed-meshheading:18573401-Interleukins,
pubmed-meshheading:18573401-Lipopolysaccharides,
pubmed-meshheading:18573401-Osteogenesis,
pubmed-meshheading:18573401-Sensitivity and Specificity
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pubmed:year |
2008
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pubmed:articleTitle |
Lipopolysaccharide stimulation of human aortic valve interstitial cells activates inflammation and osteogenesis.
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pubmed:affiliation |
Division of Cardiothoracic Surgery, University of Colorado at Denver, Denver, CO 80045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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