Linked Life Data

18573346

Source:http://linkedlifedata.com/resource/pubmed/id/18573346

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2008-8-11
pubmed:abstractText
Extinction has mostly been studied in conditioning paradigms, more sparsely in spatial tasks, and never as a function of the age of a spatial memory. Using rats, we compared the time-course of extinction of a recent (5 days) vs. remote (25 days) spatial memory in a water maze, over three probe trials. When the trials were set 24h apart, performance in the remote memory group was significantly worse on the first probe trial and significantly better on the third probe trial, as compared to the recent memory group, thereby showing differences between cognitive operations underlying recent vs. remote memory extinction. In contrast, when trials were given consecutively, both groups showed a similar profile of extinction. Furthermore, in a room with overly-salient cues providing a strong remote memory trace, no difference between groups was observed when the spaced extinction paradigm was used. These results might be related to a balance between reconsolidation and extinction processes occurring after a first retrieval experience, of which the outcome may depend on the extinction protocol, and on the age and strength of a memory.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1095-9564
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
460-6
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Differential sensitivity of recent vs. remote memory traces to extinction in a water-maze task in rats.
pubmed:affiliation
Laboratoire d'Imagerie et de Neurosciences Cognitives, UMR 7191, Université Louis Pasteur-CNRS, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, F-67000 Strasbourg, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't