Source:http://linkedlifedata.com/resource/pubmed/id/18572041
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2008-6-23
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pubmed:abstractText |
Recently, it was shown that substituting soy nuts for nonsoy protein in a therapeutic lifestyle change (TLC) diet lowered systolic and diastolic blood pressure by 9.9% and 6.8%, respectively, in postmenopausal women with hypertension and by 5.2% and 2.9%, respectively, in normotensive postmenopausal women. In this study, to examine mechanisms for these reductions, markers of inflammation were measured, including soluble vascular cell adhesion molecule-1, soluble intercellular adhesion molecule-1, C-reactive protein, interleukin-6, and matrix metalloproteinase-9. Sixty healthy postmenopausal women (48 normotensive and 12 with hypertension) were randomized in a crossover design to a TLC diet alone or a TLC diet in which 0.5 cups of soy nuts (25 g soy protein and 101 mg aglycone isoflavones) replaced 25 g of nonsoy protein daily. Each diet was followed for 8 weeks. Compared with the TLC diet alone, levels of soluble vascular cell adhesion molecule-1 were significantly lower on the soy diet in women with hypertension (623.6 +/- 153.8 vs 553.8 +/- 114.4 ng/ml, respectively, p = 0.003), whereas no significant differences were observed in normotensive women. Soy nuts were associated with a trend toward reduction in C-reactive protein in normotensive women. No effect on levels of soluble intercellular adhesion molecule-1, interleukin-6, or matrix metalloproteinase-9 was observed. In conclusion, the reduction in soluble vascular cell adhesion molecule-1 with soy nuts in women with hypertension suggests an improvement in endothelial function that may reflect an overall improvement in the underlying inflammatory process underlying atherosclerosis.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Biological Markers,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Adhesion Molecule-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Cell Adhesion Molecule-1
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0002-9149
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
84-6
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pubmed:dateRevised |
2011-10-31
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pubmed:meshHeading |
pubmed-meshheading:18572041-Biological Markers,
pubmed-meshheading:18572041-Blood Pressure,
pubmed-meshheading:18572041-C-Reactive Protein,
pubmed-meshheading:18572041-Cell Adhesion Molecules,
pubmed-meshheading:18572041-Female,
pubmed-meshheading:18572041-Humans,
pubmed-meshheading:18572041-Hypertension,
pubmed-meshheading:18572041-Inflammation,
pubmed-meshheading:18572041-Intercellular Adhesion Molecule-1,
pubmed-meshheading:18572041-Interleukin-6,
pubmed-meshheading:18572041-Isoflavones,
pubmed-meshheading:18572041-Matrix Metalloproteinase 9,
pubmed-meshheading:18572041-Postmenopause,
pubmed-meshheading:18572041-Soy Foods,
pubmed-meshheading:18572041-Soybean Proteins,
pubmed-meshheading:18572041-Vascular Cell Adhesion Molecule-1
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pubmed:year |
2008
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pubmed:articleTitle |
Effect of soy nuts on adhesion molecules and markers of inflammation in hypertensive and normotensive postmenopausal women.
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pubmed:affiliation |
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Randomized Controlled Trial,
Research Support, N.I.H., Extramural
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