18571585

Source:http://linkedlifedata.com/resource/pubmed/id/18571585

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021753, umls-concept:C0041904, umls-concept:C0334227, umls-concept:C0346647, umls-concept:C0387583, umls-concept:C1513475
pubmed:issue	1
pubmed:dateCreated	2008-6-23
pubmed:abstractText	Pancreatic cancer is a very aggressive malignancy and efficient therapeutic options are still largely lacking. The importance of interactions between tumor cells and surrounding stromal elements, eg, mononuclear cells, for chemoresistance have been increasingly recognized. In addition, cyclooxygenase-2 is thought to be an important mediator of chemoresistance in several malignancies. The aim of this study was to explore the role of mononuclear cells in pancreatic cancer chemoresistance.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/P01 AT003960, http://linkedlifedata.com/resource/pubmed/grant/P01 AT003960-01A1, http://linkedlifedata.com/resource/pubmed/grant/P30 DK041301, http://linkedlifedata.com/resource/pubmed/grant/P30 DK041301-19, http://linkedlifedata.com/resource/pubmed/grant/R01 CA104027, http://linkedlifedata.com/resource/pubmed/grant/R01 CA104027-04, http://linkedlifedata.com/resource/pubmed/grant/R01 CA122042, http://linkedlifedata.com/resource/pubmed/grant/R01 CA122042-01A1
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pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0417347
pubmed:citationSubset	AIM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cytokines, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1beta
pubmed:status	MEDLINE
pubmed:month	Jul
pubmed:issn	1532-7361
pubmed:author	pubmed-author:AngstElianeE, pubmed-author:EiblGuidoG, pubmed-author:HinesOscar JOJ, pubmed-author:ReberHoward AHA
pubmed:issnType	Electronic
pubmed:volume	144
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	57-65
pubmed:dateRevised	2011-9-26
pubmed:meshHeading	pubmed-meshheading:18571585-Apoptosis, pubmed-meshheading:18571585-Cell Line, Tumor, pubmed-meshheading:18571585-Cyclooxygenase 2, pubmed-meshheading:18571585-Cytokines, pubmed-meshheading:18571585-Drug Resistance, Neoplasm, pubmed-meshheading:18571585-Humans, pubmed-meshheading:18571585-Interleukin-1beta, pubmed-meshheading:18571585-Leukocytes, Mononuclear, pubmed-meshheading:18571585-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:18571585-Pancreatic Neoplasms, pubmed-meshheading:18571585-Up-Regulation
pubmed:year	2008
pubmed:articleTitle	Mononuclear cell-derived interleukin-1 beta confers chemoresistance in pancreatic cancer cells by upregulation of cyclooxygenase-2.
pubmed:affiliation	Hirshberg Laboratories for Pancreatic Cancer Research, CURE, Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural