Source:http://linkedlifedata.com/resource/pubmed/id/18570975
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
7
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pubmed:dateCreated |
2008-6-23
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pubmed:abstractText |
In 1994, Chang et al described a novel herpesvirus in tissues from patients with Kaposi sarcoma, referred to as Kaposi sarcoma herpesvirus or human herpesvirus 8. They used a very sophisticated technique of molecular biology to isolate unknown DNA sequences from Kaposi sarcoma lesions, which were not present in normal tissues. It turned out that these sequences corresponded to a previously unrecognized gamma herpesvirus highly homologous to human herpesvirus 4 (Epstein-Barr virus) and to herpesvirus saimiri. Contrary to Epstein-Barr virus, human herpesvirus 8 is not ubiquitous. The seroprevalence of human herpesvirus 8 varies greatly worldwide, with 1% to 10% of people being infected in developed countries and up to 80% of infected individuals in some areas of sub-Saharan and equatorial Africa. Human herpesvirus 8 is associated with a limited spectrum of tumors, mostly observed in immunodeficient individuals with HIV infection. Beside Kaposi sarcoma and multicentric Castleman disease, human herpesvirus 8 is associated with primary effusion lymphoma, but unlike Epstein-Barr virus, human herpesvirus 8 is not involved in epithelial tumors. Different proteins of the virus can be detected in infected cells. Antibodies against the latent nuclear antigen 1 are available in routine pathology and represent a powerful tool to detect the virus in human tissues. Although Epstein-Barr virus is the most frequent causative agent of lymphomas in immunocompromised individuals, a systematic screening of such tumors with specific antibodies reveals that the implication of human herpesvirus 8 infection is probably underestimated. Recent descriptions of non-Hodgkin lymphoma in endemic areas, solid localizations of primary effusion lymphoma, and posttransplantation lymphoproliferations have expanded the spectrum of human herpesvirus 8-related lymphoproliferative disorders. In this review, we will be presenting an overview of the recent concepts regarding human herpesvirus 8 and related disorders.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1532-8392
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
983-93
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pubmed:meshHeading |
pubmed-meshheading:18570975-Antigens, Viral,
pubmed-meshheading:18570975-Gene Expression Regulation, Viral,
pubmed-meshheading:18570975-Giant Lymph Node Hyperplasia,
pubmed-meshheading:18570975-Herpesvirus 8, Human,
pubmed-meshheading:18570975-Humans,
pubmed-meshheading:18570975-Immunocompromised Host,
pubmed-meshheading:18570975-Immunologic Deficiency Syndromes,
pubmed-meshheading:18570975-Lymphoma, Primary Effusion,
pubmed-meshheading:18570975-Nuclear Proteins,
pubmed-meshheading:18570975-Sarcoma, Kaposi
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pubmed:year |
2008
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pubmed:articleTitle |
Human herpesvirus 8 infections in patients with immunodeficiencies.
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pubmed:affiliation |
Service d'Anatomie et Cytologie Pathologiques, CHU Purpan, Université Paul-Sabatier, Toulouse III, F-31300 Toulouse, France.
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pubmed:publicationType |
Journal Article,
Review
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