rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018873,
umls-concept:C0035668,
umls-concept:C0086418,
umls-concept:C0172537,
umls-concept:C0185117,
umls-concept:C0302592,
umls-concept:C0392756,
umls-concept:C0965644,
umls-concept:C1333897,
umls-concept:C1704838,
umls-concept:C2346501,
umls-concept:C2911684
|
pubmed:issue |
6
|
pubmed:dateCreated |
2008-6-23
|
pubmed:abstractText |
Hypoxia inducible factor-1 alpha (HIF-1alpha) is a hypoxia-responsive factor, which commonly exists in the tissues of solid tumors. It plays crucial roles in maintaining cell energy metabolism, tumor angiogenesis and metastasis, cell proliferation and apoptosis. This study was to investigate the effect of silencing HIF-1alpha by RNA interference on the expression of matrix metalloproteinase-2 (MMP-2) in human cervical carcinoma HeLa cells, and to further explore the mechanism.
|
pubmed:language |
chi
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
1000-467X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
27
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
600-5
|
pubmed:meshHeading |
pubmed-meshheading:18570733-Animals,
pubmed-meshheading:18570733-Cadherins,
pubmed-meshheading:18570733-Female,
pubmed-meshheading:18570733-HeLa Cells,
pubmed-meshheading:18570733-Humans,
pubmed-meshheading:18570733-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:18570733-Immunohistochemistry,
pubmed-meshheading:18570733-Matrix Metalloproteinase 2,
pubmed-meshheading:18570733-Mice,
pubmed-meshheading:18570733-Mice, Inbred BALB C,
pubmed-meshheading:18570733-RNA Interference,
pubmed-meshheading:18570733-beta Catenin
|
pubmed:year |
2008
|
pubmed:articleTitle |
[Interference of HIF-1alpha by RNA reduces the expression of matrix metalloproteinase-2 in human cervical carcinoma HeLa cells].
|
pubmed:affiliation |
Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China.
|
pubmed:publicationType |
Journal Article,
English Abstract,
Research Support, Non-U.S. Gov't
|