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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-25
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pubmed:abstractText |
Twenty constituents were isolated from the n-hexane and chloroform extracts of Aristolochia constricta, a plant whose aerial parts have been used empirically in folk medicine for various purposes. The inhibitory effects of these constituents on smooth muscle contraction in isolated guinea-pig ileum were studied in order to observe their antispasmodic effects. 3,4-Dibenzyldihydrofuran-type lignans [(-)-cubebin, (-)-hinokinin, and (-)-pluviatolide] and a kaurene-type diterpene [(-)-kaur-16-en-19-oic acid] were isolated as active principals. They inhibited electrically induced and acetylcholine-induced contraction in the isolated guinea-pig ileum. In addition, 9- O-[(-)-kaur-15-en-17-oxyl]cubebin was isolated as a new diterpeno-lignan hybrid, although this constituent did not exhibit antispasmodic activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1520-6025
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pubmed:author |
pubmed-author:DominguezOswaldo PesantesOP,
pubmed-author:HiguchiYoshihiroY,
pubmed-author:HorieSyunjiS,
pubmed-author:IshikawaTsutomuT,
pubmed-author:KumamotoTakuyaT,
pubmed-author:MatsumotoKenjiroK,
pubmed-author:MochizukiMatsuriM,
pubmed-author:NakanishiWakaW,
pubmed-author:ShimokawaSatokoS,
pubmed-author:TashimaKimihitoK,
pubmed-author:WatanabeToshikoT,
pubmed-author:ZhangGangG
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pubmed:issnType |
Electronic
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1167-72
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pubmed:meshHeading |
pubmed-meshheading:18570470-4-Butyrolactone,
pubmed-meshheading:18570470-Animals,
pubmed-meshheading:18570470-Aristolochia,
pubmed-meshheading:18570470-Dioxoles,
pubmed-meshheading:18570470-Diterpenes,
pubmed-meshheading:18570470-Ecuador,
pubmed-meshheading:18570470-Guinea Pigs,
pubmed-meshheading:18570470-Ileum,
pubmed-meshheading:18570470-Lignans,
pubmed-meshheading:18570470-Medicine, Traditional,
pubmed-meshheading:18570470-Parasympatholytics,
pubmed-meshheading:18570470-Plants, Medicinal,
pubmed-meshheading:18570470-Stereoisomerism
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pubmed:year |
2008
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pubmed:articleTitle |
Chemical constituents of Aristolochia constricta: antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.
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pubmed:affiliation |
Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba 263-8522, Japan.
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pubmed:publicationType |
Journal Article
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