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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-6-23
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pubmed:abstractText |
YKL-40 is a new prognostic biomarker in cancer. The biological function is only poorly understood. This study aimed at determining the subcellular localization of YKL-40, using immunogold labeling, in normal epithelial cells and in malignant tumor cells of the breast by immunoelectron microscopy. YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast. A reduced expression of YKL-40 in relation to intermediate filaments and desmosomes was found in tumor cells. Changes in YKL-40 expression suggest that the function of YKL-40 in cells of epithelial origin may be related to cell motility and cell-cell adhesion, features associated with invasion and migration potential of tumor cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1521-0758
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:18570155-Adipokines,
pubmed-meshheading:18570155-Breast,
pubmed-meshheading:18570155-Breast Neoplasms,
pubmed-meshheading:18570155-Carcinoma, Ductal, Breast,
pubmed-meshheading:18570155-Desmosomes,
pubmed-meshheading:18570155-Female,
pubmed-meshheading:18570155-Glycoproteins,
pubmed-meshheading:18570155-Humans,
pubmed-meshheading:18570155-Immunohistochemistry,
pubmed-meshheading:18570155-Lectins,
pubmed-meshheading:18570155-Microscopy, Immunoelectron,
pubmed-meshheading:18570155-Tumor Markers, Biological
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pubmed:articleTitle |
Subcellular localization of YKL-40 in normal and malignant epithelial cells of the breast.
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pubmed:affiliation |
Department of Oncology, Herlev University Hospital, Copenhagen, Denmark. anne.roslind@dadlnet.dk
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pubmed:publicationType |
Journal Article
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