Source:http://linkedlifedata.com/resource/pubmed/id/18569609
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
15
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| pubmed:dateCreated |
2008-6-23
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| pubmed:abstractText |
Bisphenol A (BPA) is an industrial chemical with estrogenic activity. In our study, 40 rats were given BPA at 4, 40, and 400 mg/kg per day. Controls were treated with corn oil of same volume until the offspring were 30 d olds. At the end of the experiment, the expression of estrogen receptor (ER)-alpha and the mRNA levels of inerleukin (IL)-2, IL-12, interferon (IFN)-gamma, and tumor necrosis factor (TNF)-alpha in spleens were investigated by Western blotting and real-time reverse-transcription polymerase chain reaction (RT-PCR). The histopathological change of organs was observed. The results showed that bisphenol A reduced the expression of ER-alpha in males of the high-dose group in the F(0) generation and in middle- and high-dose groups of the F(1) generation (p < .05), but increased it in females in the high-dose group of the F(0) generation and in middle- and high-dose groups of the F(1) generation (p < .05). The levels of IL-2, IL-12, IFN-gamma, and TNF-alpha in spleens were downregulated in all groups in contrast to controls (p < .05). We also found some histological changes in spleens, livers, and kidneys. These findings demonstrated that bisphenol A has estrogen-like activity and might affect some immune organs and parameters.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogens, Non-Steroidal,
http://linkedlifedata.com/resource/pubmed/chemical/Phenols,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/bisphenol A
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1528-7394
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1000-8
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| pubmed:meshHeading |
pubmed-meshheading:18569609-Animals,
pubmed-meshheading:18569609-Cytokines,
pubmed-meshheading:18569609-Dose-Response Relationship, Drug,
pubmed-meshheading:18569609-Down-Regulation,
pubmed-meshheading:18569609-Estrogens, Non-Steroidal,
pubmed-meshheading:18569609-Female,
pubmed-meshheading:18569609-Gene Expression Regulation, Developmental,
pubmed-meshheading:18569609-Kidney,
pubmed-meshheading:18569609-Liver,
pubmed-meshheading:18569609-Male,
pubmed-meshheading:18569609-Organ Size,
pubmed-meshheading:18569609-Phenols,
pubmed-meshheading:18569609-Pregnancy,
pubmed-meshheading:18569609-RNA, Messenger,
pubmed-meshheading:18569609-Rats,
pubmed-meshheading:18569609-Rats, Inbred F344,
pubmed-meshheading:18569609-Receptors, Estrogen,
pubmed-meshheading:18569609-Spleen,
pubmed-meshheading:18569609-Toxicity Tests
|
| pubmed:year |
2008
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| pubmed:articleTitle |
Influence of bisphenol a on developing rat estrogen receptors and some cytokines in rats: a two-generational study.
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| pubmed:affiliation |
Department of Public Health, Shandong University, Jinan, China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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