Source:http://linkedlifedata.com/resource/pubmed/id/18568996
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2008-6-23
|
| pubmed:abstractText |
The primitive neuroectodermal tumor (PNET)/Ewing family of tumors (EFT) and desmoplastic small round cell tumor (DSRCT) portend a grave prognosis. Ongoing research in similar neurocrest-derived neoplasms has implicated both the muscarinic acetylcholine receptor (mAChR) and nicotinic acetylcholine receptor (nAChR) in the pathogenesis of these neoplasms. Acetylcholine has been reported to impart a modulatory effect on chemotaxis and proliferation, an effect ameliorated by anticholinergic drugs. The aim of our study is to characterize the pattern of expression of mAChR and nAChR in PNET/EFT and DSRCT, in hopes of discovering a potential target for therapeutic improvements. We examined 34 cases of PNET/EFT and 2 DSRCT retrospectively by immunohistochemical studies. We found that AChRs are overexpressed in a significant number of PNET/EFT and DSRCT. The Western blot analysis of 3 human Ewing sarcoma cell lines confirms the presence of AChRs. Future studies are planned to confirm these results as well as to investigate their potential therapeutic implications.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1551-3823
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
83-97
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:18568996-Adolescent,
pubmed-meshheading:18568996-Adult,
pubmed-meshheading:18568996-Aged,
pubmed-meshheading:18568996-Blotting, Western,
pubmed-meshheading:18568996-Bone Neoplasms,
pubmed-meshheading:18568996-Brain Neoplasms,
pubmed-meshheading:18568996-Cell Line, Tumor,
pubmed-meshheading:18568996-Child,
pubmed-meshheading:18568996-Female,
pubmed-meshheading:18568996-Fluorescent Antibody Technique, Indirect,
pubmed-meshheading:18568996-Humans,
pubmed-meshheading:18568996-Image Processing, Computer-Assisted,
pubmed-meshheading:18568996-Male,
pubmed-meshheading:18568996-Middle Aged,
pubmed-meshheading:18568996-Neuroectodermal Tumors, Primitive,
pubmed-meshheading:18568996-Receptors, Muscarinic,
pubmed-meshheading:18568996-Receptors, Nicotinic,
pubmed-meshheading:18568996-Retrospective Studies,
pubmed-meshheading:18568996-Sarcoma, Ewing,
pubmed-meshheading:18568996-Sarcoma, Small Cell,
pubmed-meshheading:18568996-Tissue Array Analysis,
pubmed-meshheading:18568996-Tumor Markers, Biological
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Assessment of muscarinic and nicotinic acetylcholine receptor expression in primitive neuroectodermal tumor/ewing family of tumor and desmoplastic small round cell tumor: an immunohistochemical and Western blot study of tissue microarray and cell lines.
|
| pubmed:affiliation |
Department of Anatomy, Cell Biology, and Pathology of University of South Florida, Tampa, Florida, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|