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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2008-6-23
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pubmed:abstractText |
CD133 (stem marker) and drug resistant gene (mdr1 and bcl-2) expression were detected in human glioblastoma and normal brain tissues. Glioma tissues contained higher ratio of CD133+ cells compared to normal tissues ( approximately 10 fold increase). The chemosensitivity assay showed that GOS-3 and NHA CD133+ possess greater resistance towards drugs compared to CD133- fractions. This study revealed for the first time that: a) serum deprivation enriched CD133 expression and demonstrated a direct co-expression between CD133 and drug resistant in GOS-3 cells and b) higher expression of CD133 and drug resistance were found in glioblastoma tissues in comparison to normal brain tissues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ABCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/AC133 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Serum-Free,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intermediate Filament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/nestin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1532-4192
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-42
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pubmed:meshHeading |
pubmed-meshheading:18568776-Antigens, CD,
pubmed-meshheading:18568776-Antineoplastic Agents,
pubmed-meshheading:18568776-Brain Neoplasms,
pubmed-meshheading:18568776-Cell Line, Tumor,
pubmed-meshheading:18568776-Cell Proliferation,
pubmed-meshheading:18568776-Cell Survival,
pubmed-meshheading:18568776-Culture Media, Serum-Free,
pubmed-meshheading:18568776-Dose-Response Relationship, Drug,
pubmed-meshheading:18568776-Drug Resistance, Multiple,
pubmed-meshheading:18568776-Drug Resistance, Neoplasm,
pubmed-meshheading:18568776-Flow Cytometry,
pubmed-meshheading:18568776-Gene Expression Profiling,
pubmed-meshheading:18568776-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:18568776-Glioblastoma,
pubmed-meshheading:18568776-Glycoproteins,
pubmed-meshheading:18568776-Humans,
pubmed-meshheading:18568776-Immunomagnetic Separation,
pubmed-meshheading:18568776-Inhibitory Concentration 50,
pubmed-meshheading:18568776-Intermediate Filament Proteins,
pubmed-meshheading:18568776-Neoplastic Stem Cells,
pubmed-meshheading:18568776-Nerve Tissue Proteins,
pubmed-meshheading:18568776-P-Glycoprotein,
pubmed-meshheading:18568776-Peptides,
pubmed-meshheading:18568776-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:18568776-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:18568776-Up-Regulation
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pubmed:year |
2008
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pubmed:articleTitle |
Expression of multidrug resistance genes in normal and cancer stem cells.
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pubmed:affiliation |
Brain Tumor North West, Faculty of Science and Technology, University of Central Lancashire, Preston, United Kingdom. aashervington@uclan.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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