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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2008-6-23
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pubmed:abstractText |
Despite ubiquitous expression of the keratoepithelin (KE) protein encoded by the transforming growth factor beta induced/beta induced gene human clone 3 (TGFBI/BIGH3) gene, corneal dystrophies are restricted to the cornea, and no other tissues are affected. We investigated the role of TGFBI/BIGH3 in Groenouw corneal dystrophies by generating transgenic mice overexpressing TGFBI/BIGH3 containing the R555W mutation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-10646649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-10753964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-11895005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-11923233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-12351380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-12704422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-12824240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-1418997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-14564000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-15672832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-15780949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-15939034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-16683255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-16710170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-17301843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-17591873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-17671645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-17671654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-8044658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-8602510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-9054935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-9363890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18568131-9811723
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-0535
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1129-37
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18568131-Animals,
pubmed-meshheading:18568131-Blotting, Southern,
pubmed-meshheading:18568131-Blotting, Western,
pubmed-meshheading:18568131-Electroretinography,
pubmed-meshheading:18568131-Extracellular Matrix Proteins,
pubmed-meshheading:18568131-Female,
pubmed-meshheading:18568131-Gene Expression Regulation,
pubmed-meshheading:18568131-Humans,
pubmed-meshheading:18568131-Hyperplasia,
pubmed-meshheading:18568131-Lentivirus,
pubmed-meshheading:18568131-Male,
pubmed-meshheading:18568131-Mice,
pubmed-meshheading:18568131-Mice, Transgenic,
pubmed-meshheading:18568131-Mutant Proteins,
pubmed-meshheading:18568131-Organ Size,
pubmed-meshheading:18568131-Organ Specificity,
pubmed-meshheading:18568131-Phosphoglycerate Kinase,
pubmed-meshheading:18568131-Promoter Regions, Genetic,
pubmed-meshheading:18568131-RNA, Messenger,
pubmed-meshheading:18568131-Reproducibility of Results,
pubmed-meshheading:18568131-Retinal Degeneration,
pubmed-meshheading:18568131-Spleen,
pubmed-meshheading:18568131-Transforming Growth Factor beta,
pubmed-meshheading:18568131-Virus Integration
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pubmed:year |
2008
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pubmed:articleTitle |
Overexpression of a mutant form of TGFBI/BIGH3 induces retinal degeneration in transgenic mice.
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pubmed:affiliation |
Institut de Recherche en Ophtalmologie, Sion, Switzerland. mauro.bustamante@irovision.ch
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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