Source:http://linkedlifedata.com/resource/pubmed/id/18567753
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
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| pubmed:dateCreated |
2008-6-23
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| pubmed:abstractText |
Recently, it was shown that the exposure to the potent hop phytoestrogen 8-prenylnaringenin (8-PN) depends on intestinal bacterial activation of isoxanthohumol (IX), but this occurs in only one-third of tested individuals. As the butyrate-producing Eubacterium limosum can produce 8-PN from IX, a probiotic strategy was applied to investigate whether 8-PN production could be increased in low 8-PN producers, thus balancing phytoestrogen exposure. Using fecal samples from high (Hop +) and low (Hop -) 8-PN-producing individuals, a Hop + and Hop - dynamic intestinal model was developed. In parallel, Hop + and Hop - human microbiota-associated rats were developed, germ-free (GF) rats acting as negative controls. IX and then IX + E. limosum were administered in the intestinal model and to the rats, and changes in 8-PN production and exposure were assessed. After dosing IX, 80% was converted into 8-PN in the Hop + model and highest 8-PN production, plasma concentrations, and urinary and fecal excretion occurred in the Hop + rats. Administration of the bacterium triggered 8-PN production in the GF rats and increased 8-PN production in the Hop - model and Hop - rats. 8-PN excretion was similar in the feces (294.1 +/- 132.2 nmol/d) and urine (8.5 +/- 1.1 nmol/d ) of all rats (n = 18). In addition, butyrate production increased in all rats. In conclusion, intestinal microbiota determined 8-PN production and exposure after IX intake. Moreover, E. limosum administration increased 8-PN production in low producers, resulting in similar 8-PN production in all rats.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-prenylnaringenin,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Flavanones,
http://linkedlifedata.com/resource/pubmed/chemical/Phytoestrogens,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthones,
http://linkedlifedata.com/resource/pubmed/chemical/isoxanthohumol
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
|
| pubmed:issn |
1541-6100
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| pubmed:author |
pubmed-author:BruneauAuréliaA,
pubmed-author:De KeukeleireDenisD,
pubmed-author:EspínJuan CarlosJC,
pubmed-author:González-SarríasAntonioA,
pubmed-author:HeyerickArneA,
pubmed-author:PhilippeCatherineC,
pubmed-author:PossemiersSamS,
pubmed-author:RabotSylvieS,
pubmed-author:Tomás-BarberánFrancisco AFA,
pubmed-author:VerstraeteWillyW
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| pubmed:issnType |
Electronic
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| pubmed:volume |
138
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1310-6
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| pubmed:meshHeading |
pubmed-meshheading:18567753-Animals,
pubmed-meshheading:18567753-Base Sequence,
pubmed-meshheading:18567753-Biotransformation,
pubmed-meshheading:18567753-DNA, Bacterial,
pubmed-meshheading:18567753-DNA Primers,
pubmed-meshheading:18567753-Diet,
pubmed-meshheading:18567753-Eubacterium,
pubmed-meshheading:18567753-Female,
pubmed-meshheading:18567753-Flavanones,
pubmed-meshheading:18567753-Germ-Free Life,
pubmed-meshheading:18567753-Humans,
pubmed-meshheading:18567753-Humulus,
pubmed-meshheading:18567753-Intestines,
pubmed-meshheading:18567753-Male,
pubmed-meshheading:18567753-Phytoestrogens,
pubmed-meshheading:18567753-Polymerase Chain Reaction,
pubmed-meshheading:18567753-Probiotics,
pubmed-meshheading:18567753-Rats,
pubmed-meshheading:18567753-Rats, Inbred F344,
pubmed-meshheading:18567753-Xanthones
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| pubmed:year |
2008
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| pubmed:articleTitle |
Eubacterium limosum activates isoxanthohumol from hops (Humulus lupulus L.) into the potent phytoestrogen 8-prenylnaringenin in vitro and in rat intestine.
|
| pubmed:affiliation |
Laboratory of Microbial Ecology and Technology, Faculty of Bioscience Engineering, Ghent University, B-9000 Gent, Belgium.
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|