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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5886
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pubmed:dateCreated |
2008-7-14
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pubmed:abstractText |
The control of innate immune responses through activation of the nuclear transcription factor NF-kappaB is essential for the elimination of invading microbial pathogens. We showed that the bacterial N-(3-oxo-dodecanoyl) homoserine lactone (C12) selectively impairs the regulation of NF-kappaB functions in activated mammalian cells. The consequence is specific repression of stimulus-mediated induction of NF-kappaB-responsive genes encoding inflammatory cytokines and other immune regulators. These findings uncover a strategy by which C12-producing opportunistic pathogens, such as Pseudomonas aeruginosa, attenuate the innate immune system to establish and maintain local persistent infection in humans, for example, in cystic fibrosis patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/4-Butyrolactone,
http://linkedlifedata.com/resource/pubmed/chemical/Creb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Homoserine,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/I-kappa B Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/N-(3-oxododecanoyl)homoserine...,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappaB inhibitor alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Rela protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptors,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor RelA
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
321
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
259-63
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:18566250-4-Butyrolactone,
pubmed-meshheading:18566250-Adult,
pubmed-meshheading:18566250-Animals,
pubmed-meshheading:18566250-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:18566250-Cystic Fibrosis,
pubmed-meshheading:18566250-Female,
pubmed-meshheading:18566250-Gene Expression Regulation,
pubmed-meshheading:18566250-Homoserine,
pubmed-meshheading:18566250-Humans,
pubmed-meshheading:18566250-I-kappa B Kinase,
pubmed-meshheading:18566250-I-kappa B Proteins,
pubmed-meshheading:18566250-Immunity, Innate,
pubmed-meshheading:18566250-Interferon-gamma,
pubmed-meshheading:18566250-Lipopolysaccharides,
pubmed-meshheading:18566250-Macrophage Activation,
pubmed-meshheading:18566250-Macrophages,
pubmed-meshheading:18566250-Male,
pubmed-meshheading:18566250-Mice,
pubmed-meshheading:18566250-Mice, Inbred C57BL,
pubmed-meshheading:18566250-Mice, Transgenic,
pubmed-meshheading:18566250-Middle Aged,
pubmed-meshheading:18566250-NF-kappa B,
pubmed-meshheading:18566250-Phosphorylation,
pubmed-meshheading:18566250-Pseudomonas Infections,
pubmed-meshheading:18566250-Pseudomonas aeruginosa,
pubmed-meshheading:18566250-Signal Transduction,
pubmed-meshheading:18566250-Toll-Like Receptors,
pubmed-meshheading:18566250-Transcription Factor RelA
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pubmed:year |
2008
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pubmed:articleTitle |
Modulation of gene expression via disruption of NF-kappaB signaling by a bacterial small molecule.
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pubmed:affiliation |
Department of Immunology and Microbial Sciences, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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