Source:http://linkedlifedata.com/resource/pubmed/id/18565849
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2008-8-26
|
| pubmed:abstractText |
Expression of CD7, ELA-2, PR-3, and the polycomb group gene BMI-1 reflects the intrinsic heterogeneity and predicts prognosis of patients with chronic myeloid leukemia (CML) who were not treated with allogeneic stem cell transplantation (allo-SCT). This study investigated whether expression of these genes determined outcome following allo-SCT in a cohort of 84 patients with chronic-phase (CP) CML. We found that patients expressing BMI-1 at a "high" level before allo-SCT had an improved overall survival (P = .005) related to a reduced transplantation-related mortality. In multivariate analysis, when adjusted for the European Group for Blood and Marrow Transplantation (EBMT)-Gratwohl score and other prog-nostic factors, there was an independent association between BMI-1 expression and grades 2 to 4 acute graft-versus-host disease (relative risk [RR] = 2.85; 95% confidence interval [CI], 1.3-6.4; P = .011), suggesting that BMI-1 measured prior to allo-SCT can serve as a biomarker for predicting outcome in patients with CP-CML receiving allo-SCT, and may thus contribute to better therapeutic decisions.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BMI1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1528-0020
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
1
|
| pubmed:volume |
112
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2163-6
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| pubmed:meshHeading |
pubmed-meshheading:18565849-Acute Disease,
pubmed-meshheading:18565849-Adolescent,
pubmed-meshheading:18565849-Adult,
pubmed-meshheading:18565849-Child,
pubmed-meshheading:18565849-Child, Preschool,
pubmed-meshheading:18565849-Female,
pubmed-meshheading:18565849-Gene Expression,
pubmed-meshheading:18565849-Graft vs Host Disease,
pubmed-meshheading:18565849-HLA Antigens,
pubmed-meshheading:18565849-Humans,
pubmed-meshheading:18565849-Leukemia, Myeloid, Chronic-Phase,
pubmed-meshheading:18565849-Male,
pubmed-meshheading:18565849-Middle Aged,
pubmed-meshheading:18565849-Nuclear Proteins,
pubmed-meshheading:18565849-Prognosis,
pubmed-meshheading:18565849-Proto-Oncogene Proteins,
pubmed-meshheading:18565849-Repressor Proteins,
pubmed-meshheading:18565849-Siblings,
pubmed-meshheading:18565849-Stem Cell Transplantation
|
| pubmed:year |
2008
|
| pubmed:articleTitle |
Association between BMI-1 expression, acute graft-versus-host disease, and outcome following allogeneic stem cell transplantation from HLA-identical siblings in chronic myeloid leukemia.
|
| pubmed:affiliation |
Department of Haematology, Imperial College London, Hammersmith Hospital, London, United Kingdom.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|