|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
14
|
|
pubmed:dateCreated |
2008-7-25
|
|
pubmed:abstractText |
A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%).
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
1464-3391
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
16
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6747-51
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:18565754-Aldehyde Reductase,
pubmed-meshheading:18565754-Animals,
pubmed-meshheading:18565754-Cell Line,
pubmed-meshheading:18565754-Glucose,
pubmed-meshheading:18565754-Humans,
pubmed-meshheading:18565754-Hypoglycemic Agents,
pubmed-meshheading:18565754-Insulin,
pubmed-meshheading:18565754-Kidney,
pubmed-meshheading:18565754-Male,
pubmed-meshheading:18565754-Mice,
pubmed-meshheading:18565754-Rats,
pubmed-meshheading:18565754-Thiazolidinediones
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Synthesis and biological activity of some new flavonyl-2,4-thiazolidinediones.
|
|
pubmed:affiliation |
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100 Tando?an, Ankara, Turkey. bozdag@pharmacy.ankara.edu.tr
|
|
pubmed:publicationType |
Journal Article
|
