Linked Life Data

18563560

Source:http://linkedlifedata.com/resource/pubmed/id/18563560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-1-26
pubmed:abstractText
The preventive effect of dietary taurine supplementation on glial alterations in retina of streptozotocin-induced diabetic rats was examined in this study. Blood glucose content, content of taurine, glutamate and <gamma>-amino butyric acid (GABA) and expression of glial fibrillary acid protein (GFAP), vascular endothelial growth factor (VEGF), glutamate transporter (GLAST), glutamine synthetase (GS) and glutamate decarboxylase (GAD) in retina were determined in diabetic rats fed without or with 5% taurine in a controlled trial lasting 12 weeks, with normal rats fed without or with 5% taurine served as controls. Dietary taurine supplementation could not lower glucose concentration in blood (P > 0.05), but caused an elevation of taurine content and a decline in levels of glutamate and GABA in retina of diabetic rats (P < 0.05). The content of GABA in normal control group was not altered by taurine supplementation. With supplementation of taurine in diet, lower expression of GFAP and VEGF while higher expression of GLAST, GS and GAD in retina of diabetic rats were determinated by RT-PCR, Western-blotting and immunofluorescence (P < 0.05). GFAP, VEGF, GLAST, GS and GAD expressions in normal controls were not altered by taurine treatment. This may have prospective implications of using taurine to treat complications in diabetic retinopathy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1573-6903
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
244-54
pubmed:meshHeading
pubmed-meshheading:18563560-Animals, pubmed-meshheading:18563560-Base Sequence, pubmed-meshheading:18563560-DNA Primers, pubmed-meshheading:18563560-Diabetes Mellitus, Experimental, pubmed-meshheading:18563560-Fluorescent Antibody Technique, pubmed-meshheading:18563560-Glial Fibrillary Acidic Protein, pubmed-meshheading:18563560-Glutamate Decarboxylase, pubmed-meshheading:18563560-Glutamate-Ammonia Ligase, pubmed-meshheading:18563560-Neuroglia, pubmed-meshheading:18563560-Rats, pubmed-meshheading:18563560-Rats, Sprague-Dawley, pubmed-meshheading:18563560-Retina, pubmed-meshheading:18563560-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:18563560-Taurine, pubmed-meshheading:18563560-Vascular Endothelial Growth Factor A, pubmed-meshheading:18563560-gamma-Aminobutyric Acid
pubmed:year
2009
pubmed:articleTitle
Dietary taurine supplementation prevents glial alterations in retina of diabetic rats.
pubmed:affiliation
Department of Nutrition and Food Hygiene, School of Preventive Medicine, The Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing, 400038, People's Republic of China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't