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rdf:type |
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lifeskim:mentions |
umls-concept:C0007613,
umls-concept:C0021051,
umls-concept:C0025914,
umls-concept:C0026336,
umls-concept:C0026809,
umls-concept:C0026882,
umls-concept:C0038250,
umls-concept:C0086418,
umls-concept:C0242767,
umls-concept:C0330390,
umls-concept:C0936012,
umls-concept:C1186763,
umls-concept:C1527178,
umls-concept:C1705938
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pubmed:issue |
8
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pubmed:dateCreated |
2008-7-28
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pubmed:abstractText |
To develop and validate a new immunodeficient mouse strain that spontaneously develops a non-autoimmune hyperglycaemia to serve as a diabetic host for human islets and human beta stem and progenitor cells without the need for induction of hyperglycaemia by toxic chemicals with their associated side effects.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-11981430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-12464347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-12540615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-14557749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-15064419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-15308121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-15879151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-16099998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-16456127,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-17212763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-17259968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-17332083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-17761203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-17786244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-17891462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-18045145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-18096436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-2191887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-2852569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-3046975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-3512604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-4241908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-6381036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-6452996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-7995938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-9133560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-9593767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18563383-9617892
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-186X
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pubmed:author |
pubmed-author:BottinoRR,
pubmed-author:BurzenskiLL,
pubmed-author:ChaseTT,
pubmed-author:ForemanOO,
pubmed-author:GotoII,
pubmed-author:GreinerD LDL,
pubmed-author:LiefJJ,
pubmed-author:PearsonTT,
pubmed-author:RossiniA AAA,
pubmed-author:ShultzL DLD,
pubmed-author:TruccoMM
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1449-56
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:18563383-Animals,
pubmed-meshheading:18563383-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:18563383-Disease Models, Animal,
pubmed-meshheading:18563383-Humans,
pubmed-meshheading:18563383-Hyperglycemia,
pubmed-meshheading:18563383-Insulin-Secreting Cells,
pubmed-meshheading:18563383-Islets of Langerhans,
pubmed-meshheading:18563383-Islets of Langerhans Transplantation,
pubmed-meshheading:18563383-Mice,
pubmed-meshheading:18563383-Mice, Inbred NOD,
pubmed-meshheading:18563383-Mutation,
pubmed-meshheading:18563383-Receptors, Interleukin-2,
pubmed-meshheading:18563383-Severe Combined Immunodeficiency,
pubmed-meshheading:18563383-Transplantation, Heterologous
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pubmed:year |
2008
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pubmed:articleTitle |
A new immunodeficient hyperglycaemic mouse model based on the Ins2Akita mutation for analyses of human islet and beta stem and progenitor cell function.
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pubmed:affiliation |
Diabetes Division, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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