|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
33
|
|
pubmed:dateCreated |
2008-7-21
|
|
pubmed:abstractText |
Two recombinant plasmids pVAX/Sj26GST and pVAX/mIL-18 containing Schistosoma japonicum 26kDa GST and murine IL-18 were evaluated for their ability to protect mice against S. japonicum challenge. Mice were given 2 intramuscular immunizations 3 weeks apart, and challenged with S. japonicum cercariae 4 weeks later. Adult worm and egg burdens were determined 48 days post-challenge. All animals vaccinated with pVAX/Sj26GST alone or with pVAX/mIL-18 developed specific anti-SWAP (soluble worm antigen preparation) ELISA antibody and splenocyte proliferation response. Co-injection of pVAX/mIL-18 significantly increased the production of IFN-gamma and IL-12, indicating that IL-18 enhances the Th1-dominant immune response. Challenge experiments showed that worms were reduced in the pVAX/Sj26GST group by 30.1% and by 49.4% in animals given pVAX/mIL-18 additionally. Corresponding hepatic and fecal egg reductions were 44.8% and 53.0%, and 50.6% and 56.6%, respectively. These results indicate that IL-18 may be an effective adjuvant for a schistosomiasis vaccine.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Helminth,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione Transferase,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-18,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0264-410X
|
|
pubmed:author |
pubmed-author:FengWeiW,
pubmed-author:FuZhiqiangZ,
pubmed-author:GaoShengyanS,
pubmed-author:JidahJJ,
pubmed-author:LinJiaojiaoJ,
pubmed-author:LiuQuanQ,
pubmed-author:MenJingtaoJ,
pubmed-author:ShengLiqinL,
pubmed-author:ShiYaojunY,
pubmed-author:XiaZhipingZ,
pubmed-author:ZhaiYujiaY,
pubmed-author:ZhuXing-QuanXQ
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
26
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4145-9
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:18562051-Adjuvants, Immunologic,
pubmed-meshheading:18562051-Animals,
pubmed-meshheading:18562051-Antibodies, Helminth,
pubmed-meshheading:18562051-Antigens, Helminth,
pubmed-meshheading:18562051-Cell Proliferation,
pubmed-meshheading:18562051-Feces,
pubmed-meshheading:18562051-Female,
pubmed-meshheading:18562051-Glutathione Transferase,
pubmed-meshheading:18562051-Immunization, Secondary,
pubmed-meshheading:18562051-Injections, Intramuscular,
pubmed-meshheading:18562051-Interferon-gamma,
pubmed-meshheading:18562051-Interleukin-12,
pubmed-meshheading:18562051-Interleukin-18,
pubmed-meshheading:18562051-Liver,
pubmed-meshheading:18562051-Lymphocytes,
pubmed-meshheading:18562051-Mice,
pubmed-meshheading:18562051-Mice, Inbred BALB C,
pubmed-meshheading:18562051-Parasite Egg Count,
pubmed-meshheading:18562051-Plasmids,
pubmed-meshheading:18562051-Schistosoma japonicum,
pubmed-meshheading:18562051-Schistosomiasis japonica,
pubmed-meshheading:18562051-Spleen,
pubmed-meshheading:18562051-Vaccines, DNA
|
|
pubmed:year |
2008
|
|
pubmed:articleTitle |
Enhancement by IL-18 of the protective effect of a Schistosoma japonicum 26kDa GST plasmid DNA vaccine in mice.
|
|
pubmed:affiliation |
Laboratory of Parasitology, Veterinary Institute, Academy of Military Medical Sciences, 1068 Qinglong Road, Changchun 130062, China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
