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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2008-6-18
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pubmed:abstractText |
The mouse double minute 2 homologue (MDM2) -309T/G promoter polymorphism has been associated recently with the development and prognosis of a variety of tumors. The G allele is associated with increased affinity for Sp1 binding and higher MDM2 mRNA and protein levels, leading to diminished tumor suppressor activity of the p53 pathway. We hypothesized that the G allele is also associated with increased risk and worse outcome in pancreatic cancer.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:AsomaningKofiK,
pubmed-author:BlaszkowskyLawrenceL,
pubmed-author:ChristianiDavid CDC,
pubmed-author:HeistRebecca SRS,
pubmed-author:KwakEunice LEL,
pubmed-author:LiuGeoffreyG,
pubmed-author:ReidAmy EAE,
pubmed-author:RyanDavid PDP,
pubmed-author:SUKhKh,
pubmed-author:ZhaiRihongR,
pubmed-author:ZhouWeiW,
pubmed-author:ZhuAndrew XAX
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4010-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:18559624-Adenocarcinoma,
pubmed-meshheading:18559624-Adult,
pubmed-meshheading:18559624-Aged,
pubmed-meshheading:18559624-Aged, 80 and over,
pubmed-meshheading:18559624-Case-Control Studies,
pubmed-meshheading:18559624-Female,
pubmed-meshheading:18559624-Genetic Predisposition to Disease,
pubmed-meshheading:18559624-Humans,
pubmed-meshheading:18559624-Male,
pubmed-meshheading:18559624-Middle Aged,
pubmed-meshheading:18559624-Pancreatic Neoplasms,
pubmed-meshheading:18559624-Polymorphism, Genetic,
pubmed-meshheading:18559624-Prognosis,
pubmed-meshheading:18559624-Promoter Regions, Genetic,
pubmed-meshheading:18559624-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:18559624-Risk,
pubmed-meshheading:18559624-Survival Analysis
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pubmed:year |
2008
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pubmed:articleTitle |
MDM2 promoter polymorphism and pancreatic cancer risk and prognosis.
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pubmed:affiliation |
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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