Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
28
pubmed:dateCreated
2008-7-8
pubmed:abstractText
Werner syndrome is a rare human disease characterized by the premature onset of aging-associated pathologies, cancer predisposition, and genomic instability. The Werner protein (WRN), which is defective in Werner syndrome ( WS) patients, belongs to the RecQ family helicases and interacts with several DNA metabolic proteins, including DNA repair factors and telomere associated proteins. Nonhomologous end-joining (NHEJ) is an important pathway in the repair of DNA double strand breaks (DSBs), and the DNA-PK complex, composed of the heterodimer Ku 70/86 and the DNA-PK catalytic subunit (DNA-PKcs), together with the XRCC4-DNA ligase IV complex (X4L4), are major factors. One of the most prominent protein interactions of WRN is with Ku 70/86, and it is possible that WRN is involved in NHEJ via its associations with Ku 70/86 and DNA-PKcs. This study demonstrates that WRN physically interacts with the major NHEJ factor, X4L4, which stimulates WRN exonuclease but not its helicase activity. The human RecQ helicase, BLM, which possesses only helicase activity, does not bind to X4L4, and its helicase activity is not affected by X4L4. In a DNA end-joining assay, we find that a substrate, which is processed by WRN, is ligated by X4L4, thus further supporting the significance of their functional interaction.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10047779, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10373438, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10377944, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10446247, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10608841, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10757784, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10781066, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10783163, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10825162, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-10880455, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11110789, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11152456, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11283371, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11477099, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11572872, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11598021, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-11889123, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-12019152, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-12077346, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-12771022, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-14576316, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-14726021, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-15279766, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-15509577, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-15574326, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-15899791, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-15907771, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-16082219, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-16141234, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-16358361, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-16439205, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-16449207, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-16622405, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-17290226, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-17915942, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-2767047, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-3909765, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-6828386, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-8700231, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9259561, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9288107, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9294146, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9611231, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9771700, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9823897, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9875844, http://linkedlifedata.com/resource/pubmed/commentcorrection/18558713-9990036
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1520-4995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7548-56
pubmed:dateRevised
2010-12-17
pubmed:meshHeading
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