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rdf:type |
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lifeskim:mentions |
umls-concept:C0035647,
umls-concept:C0036751,
umls-concept:C0041252,
umls-concept:C0087111,
umls-concept:C0205100,
umls-concept:C0205314,
umls-concept:C0243077,
umls-concept:C0441889,
umls-concept:C0559031,
umls-concept:C0679622,
umls-concept:C1709059
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pubmed:issue |
13
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pubmed:dateCreated |
2008-7-3
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pubmed:abstractText |
The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in in vitro biochemical and cell-based assays, and it selectively reduces serotonin levels in the murine intestine after oral administration without affecting levels in the brain. These TPH1 inhibitors may provide novel treatments for gastrointestinal disorders associated with dysregulation of the serotonergic system, such as chemotherapy-induced emesis and irritable bowel syndrome.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1520-4804
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pubmed:author |
pubmed-author:BuxtonEricE,
pubmed-author:DevasagayarajArokiasamyA,
pubmed-author:GuKunjianK,
pubmed-author:JinHaihongH,
pubmed-author:KimballS DavidSD,
pubmed-author:LiuQingyunQ,
pubmed-author:MainAlan JAJ,
pubmed-author:MarinelliBrettB,
pubmed-author:NguyenNghiN,
pubmed-author:NouraldeenAmrA,
pubmed-author:PatelShivS,
pubmed-author:PowellDavid RDR,
pubmed-author:SamalaLakshmanL,
pubmed-author:SheldonScottS,
pubmed-author:ShiZhi-CaiZC,
pubmed-author:StouchTerryT,
pubmed-author:SunWeimeiW,
pubmed-author:SwaffieldJonJ,
pubmed-author:TunooriAshokA,
pubmed-author:WangYingY,
pubmed-author:WilsonAlanA,
pubmed-author:YangQiQ,
pubmed-author:YuXiang-QingXQ,
pubmed-author:ZangYiY,
pubmed-author:ZhangChengminC
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3684-7
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pubmed:meshHeading |
pubmed-meshheading:18557609-Animals,
pubmed-meshheading:18557609-Cell Line,
pubmed-meshheading:18557609-Cross-Linking Reagents,
pubmed-meshheading:18557609-Crystallography, X-Ray,
pubmed-meshheading:18557609-Enzyme Inhibitors,
pubmed-meshheading:18557609-Gastrointestinal Diseases,
pubmed-meshheading:18557609-Humans,
pubmed-meshheading:18557609-Inhibitory Concentration 50,
pubmed-meshheading:18557609-Mice,
pubmed-meshheading:18557609-Models, Molecular,
pubmed-meshheading:18557609-Molecular Structure,
pubmed-meshheading:18557609-Rats,
pubmed-meshheading:18557609-Serotonin,
pubmed-meshheading:18557609-Structure-Activity Relationship,
pubmed-meshheading:18557609-Tryptophan Hydroxylase
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pubmed:year |
2008
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pubmed:articleTitle |
Modulation of peripheral serotonin levels by novel tryptophan hydroxylase inhibitors for the potential treatment of functional gastrointestinal disorders.
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pubmed:affiliation |
Lexicon Pharmaceuticals, 350 Carter Road, Princeton, New Jersey 08540, USA. zshi@lexpharma.com
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pubmed:publicationType |
Journal Article
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