18556572

Source:http://linkedlifedata.com/resource/pubmed/id/18556572

Download in:

Switch to

Custom View

Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0041904, umls-concept:C0055729, umls-concept:C0086418, umls-concept:C0205252, umls-concept:C0225336, umls-concept:C0231337, umls-concept:C0311404, umls-concept:C1423062
pubmed:issue	9
pubmed:dateCreated	2008-8-21
pubmed:abstractText	Cilostazol, a selective inhibitor of PDE3, has a protective effect on endothelium after ischemic vascular damage, through production of nitric oxide (NO). The purpose of the present study was to clarify the molecular mechanisms underlying the preventive effect of treatment with cilostazol on oxidative stress-induced premature senescence in human endothelial cells.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/18556572-18716320
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9505803
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Benzamides, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide..., http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Hydrogen Peroxide, http://linkedlifedata.com/resource/pubmed/chemical/NOS3 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Naphthols, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide, http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III, http://linkedlifedata.com/resource/pubmed/chemical/Oxidants, http://linkedlifedata.com/resource/pubmed/chemical/Paraquat, http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase 3 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Phosphodiesterase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1, http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt, http://linkedlifedata.com/resource/pubmed/chemical/SERPINE1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/SIRT1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 1, http://linkedlifedata.com/resource/pubmed/chemical/Sirtuins, http://linkedlifedata.com/resource/pubmed/chemical/TP53 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Tetrazoles, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p53, http://linkedlifedata.com/resource/pubmed/chemical/cilostazol, http://linkedlifedata.com/resource/pubmed/chemical/sirtinol
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1524-4636
pubmed:author	pubmed-author:AkishitaMasahiroM, pubmed-author:EtoMasatoM, pubmed-author:IijimaKatsuyaK, pubmed-author:KanoMitsunobu RMR, pubmed-author:OgawaSumitoS, pubmed-author:OtaHidetakaH, pubmed-author:OuchiYasuyoshiY
pubmed:issnType	Electronic
pubmed:volume	28
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1634-9
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:18556572-Acetylation, pubmed-meshheading:18556572-Animals, pubmed-meshheading:18556572-Benzamides, pubmed-meshheading:18556572-Cell Aging, pubmed-meshheading:18556572-Cell Shape, pubmed-meshheading:18556572-Cells, Cultured, pubmed-meshheading:18556572-Cyclic AMP, pubmed-meshheading:18556572-Cyclic Nucleotide Phosphodiesterases, Type 3, pubmed-meshheading:18556572-Diabetes Mellitus, Experimental, pubmed-meshheading:18556572-Dose-Response Relationship, Drug, pubmed-meshheading:18556572-Endothelial Cells, pubmed-meshheading:18556572-Enzyme Inhibitors, pubmed-meshheading:18556572-Humans, pubmed-meshheading:18556572-Hydrogen Peroxide, pubmed-meshheading:18556572-Mice, pubmed-meshheading:18556572-Mice, Inbred BALB C, pubmed-meshheading:18556572-Naphthols, pubmed-meshheading:18556572-Nitric Oxide, pubmed-meshheading:18556572-Nitric Oxide Synthase Type III, pubmed-meshheading:18556572-Oxidants, pubmed-meshheading:18556572-Oxidative Stress, pubmed-meshheading:18556572-Paraquat, pubmed-meshheading:18556572-Phosphodiesterase 3 Inhibitors, pubmed-meshheading:18556572-Phosphodiesterase Inhibitors, pubmed-meshheading:18556572-Phosphorylation, pubmed-meshheading:18556572-Plasminogen Activator Inhibitor 1, pubmed-meshheading:18556572-Proto-Oncogene Proteins c-akt, pubmed-meshheading:18556572-Sirtuin 1, pubmed-meshheading:18556572-Sirtuins, pubmed-meshheading:18556572-Tetrazoles, pubmed-meshheading:18556572-Time Factors, pubmed-meshheading:18556572-Tumor Suppressor Protein p53, pubmed-meshheading:18556572-Up-Regulation
pubmed:year	2008
pubmed:articleTitle	Cilostazol inhibits oxidative stress-induced premature senescence via upregulation of Sirt1 in human endothelial cells.
pubmed:affiliation	Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't