Linked Life Data

18555888

Source:http://linkedlifedata.com/resource/pubmed/id/18555888

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pubmed-article:18555888pubmed:abstractTextHIV-1 impairs the production of T cells, through mechanisms that are still unknown. Here, we investigated the effect of the expression of HIV-1 Nef on the T-cell potential of human hematopoietic CD34(+) precursors. Those progenitors were transduced by using lentiviral vectors expressing Nef and cultured on OP9-DL1 cells allowing the differentiation of T cell from human hematopoietic precursors. We demonstrate that Nef impairs the generation of a CD3epsilon(+)CD5(+) CD1a(+) precursor stage that has initiated a D-J rearrangement of the TCRbeta locus. Onward stages of T-cell development were also affected with a quantitative reduction of CD4(+) intraCD3epsilon(+) Immature single positive cells (ISP), Double Positive (DP) CD4(+)CD8(+) TCRalphabeta T cells and CD56(+) NK cells. But B cell production was not affected. Limiting dilution analyses demonstrated a significant reduction in the frequency of T/NK progenitors among Nef-expressing CD34(+) cells. Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential.lld:pubmed
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pubmed-article:18555888pubmed:year2008lld:pubmed
pubmed-article:18555888pubmed:articleTitleHIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor.lld:pubmed
pubmed-article:18555888pubmed:affiliationINSERM U 841, Faculté de Médecine, Créteil, France.lld:pubmed
pubmed-article:18555888pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:18555888pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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