Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2008-6-16
pubmed:abstractText
The prevailing view of intra-Golgi transport is cisternal progression, which has a key prediction--that newly arrived cargo exhibits a lag or transit time before exiting the Golgi. Instead, we find that cargo molecules exit at an exponential rate proportional to their total Golgi abundance with no lag. Incoming cargo molecules rapidly mix with those already in the system and exit from partitioned domains with no cargo privileged for export based on its time of entry into the system. Given these results, we constructed a new model of intra-Golgi transport that involves rapid partitioning of enzymes and transmembrane cargo between two lipid phases combined with relatively rapid exchange among cisternae. Simulation and experimental testing of this rapid partitioning model reproduced all the key characteristics of the Golgi apparatus, including polarized lipid and protein gradients, exponential cargo export kinetics, and cargo waves.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-10087259, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-10629217, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-10975524, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-11208161, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-11352825, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-11408588, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-11581500, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-11707151, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-12609909, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-14990965, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-15086783, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-15261669, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-15569243, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-15598467, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-16699523, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-16699524, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-1682055, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-16824007, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-17687330, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-18555771, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-2013819, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-3095318, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-6223041, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-6315743, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-6538481, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-6863900, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-7017713, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-7615680, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-8362242, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-9288971, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-9315681, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-9805000, http://linkedlifedata.com/resource/pubmed/commentcorrection/18555781-9875853
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1097-4172
pubmed:author
pubmed:issnType
Electronic
pubmed:day
13
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1055-67
pubmed:dateRevised
2011-9-26
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Transport through the Golgi apparatus by rapid partitioning within a two-phase membrane system.
pubmed:affiliation
Cell Biology and Metabolism Program, National Institutes of Health, Building 18T, Room 101, 18 Library Drive, Bethesda, MD 20892-5430, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural