Source:http://linkedlifedata.com/resource/pubmed/id/18555215
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-3
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| pubmed:dateCreated |
2008-7-28
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| pubmed:abstractText |
The purpose of this study is to elucidate the effect of IL-6 on the vasomotor reactivity of the corpus cavernosum of the rats. The strips were either left untreated or treated with 1 ng/ml of IL-6 for 60 min. By increasing concentrations of phenylephrine, acetylcholine, or sodium nitroprusside, we assessed concentration-contraction or relaxation responses. The IL-6-treated strips were incubated for 30 min with or without L-NAME (N(W)-nitro-L-arginine methyl ester), L-arginine, indomethacin, BQ-123 (an endothelin receptor A inhibitor), or SQ 29,548 (a thromboxane A(2) [TXA(2)] receptor blocker), and the effects on phenylephrine-induced contraction or acetylcholine-induced relaxation of phenylephrine-induced contraction were measured. The contractile responses to phenylephrine were significantly enhanced in the IL-6-treated strips, compared with the IL-6-nontreated strips, and the relaxation responses to acetylcholine were significantly inhibited in the IL-6-treated group compared with the IL-6-nontreated group. But after endothelial denudation, there was no difference between the IL-6-treated strips and the IL-6-nontreated strips on the contraction-relaxation responses to phenylephrine or acetylcholine. The relaxation responses to sodium nitroprusside were not inhibited in both groups. L-NAME completely inhibited the relaxation response to acetylcholine in the IL-6-treated strips, as well as the IL-6-nontreated strips. Indomethacin and SQ 29,548 significantly inhibited the increased contractile responses to phenylephrine in the IL-6-treated strips. But BQ 123 rarely affected the same responses. L-arginine reversed the inhibited relaxation responses to acetylcholine in the IL-6-treated strips. Therefore, IL-6 inhibits endothelium-dependent, NO-mediated relaxation and also enhances alpha(1)-adrenergic receptor-mediated contraction via an endothelium-dependent TXA(2)-mediated mechanism in the corpus cavernosum of the rat.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelins,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Thromboxane A2,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0014-2999
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:day |
28
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| pubmed:volume |
589
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
228-32
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| pubmed:meshHeading |
pubmed-meshheading:18555215-Animals,
pubmed-meshheading:18555215-Cyclooxygenase Inhibitors,
pubmed-meshheading:18555215-Dose-Response Relationship, Drug,
pubmed-meshheading:18555215-Endothelins,
pubmed-meshheading:18555215-Endothelium, Vascular,
pubmed-meshheading:18555215-Enzyme Inhibitors,
pubmed-meshheading:18555215-Interleukin-6,
pubmed-meshheading:18555215-Male,
pubmed-meshheading:18555215-Muscle, Smooth, Vascular,
pubmed-meshheading:18555215-Nitric Oxide,
pubmed-meshheading:18555215-Nitric Oxide Synthase,
pubmed-meshheading:18555215-Penis,
pubmed-meshheading:18555215-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:18555215-Rats,
pubmed-meshheading:18555215-Rats, Sprague-Dawley,
pubmed-meshheading:18555215-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:18555215-Thromboxane A2,
pubmed-meshheading:18555215-Vasoconstriction,
pubmed-meshheading:18555215-Vasoconstrictor Agents,
pubmed-meshheading:18555215-Vasodilation,
pubmed-meshheading:18555215-Vasodilator Agents
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| pubmed:year |
2008
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| pubmed:articleTitle |
The effects of interleukin-6 on the contraction and relaxation responses of the cavernous smooth muscle from rats.
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| pubmed:affiliation |
Department of Urology, Chung-Ang University Hospital, Seoul, Republic of Korea.
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| pubmed:publicationType |
Journal Article
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