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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2008-6-16
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pubmed:abstractText |
Mycophenolic acid (MPA) is an effective immunosuppressive treatment for renal transplant recipients, but its effective use and best practice are not established in cardiac transplantation. This multicenter, single-blind, randomized, parallel group clinical trial prospectively evaluated the therapeutic equivalence of enteric-coated mycophenolate-sodium (EC-MPS) versus mycophenolate mofetil (MMF) in combination with cyclosporine (CyA) and steroids as determined by the primary objective of treatment efficacy during the first 6 months of treatment in 154 de novo heart transplant recipients. Both groups received equivalent doses of MPA, either 720 mg b.i.d EC-MPS or 1000 mg b.i.d MMF. EC-MPS showed a comparable efficacy and safety profile compared with MMF with significantly less dose reduction. Treatment failure occurred in 57.7% and 60.5% with EC-MPS and MMF, respectively, EC-MPS was therapeutically equivalent to MMF in cardiac transplantation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0041-1345
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
953-5
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pubmed:dateRevised |
2008-10-3
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pubmed:meshHeading |
pubmed-meshheading:18555088-Adolescent,
pubmed-meshheading:18555088-Adult,
pubmed-meshheading:18555088-Aged,
pubmed-meshheading:18555088-Cyclosporine,
pubmed-meshheading:18555088-Drug Therapy, Combination,
pubmed-meshheading:18555088-Female,
pubmed-meshheading:18555088-Graft Rejection,
pubmed-meshheading:18555088-Heart Transplantation,
pubmed-meshheading:18555088-Humans,
pubmed-meshheading:18555088-Immunosuppressive Agents,
pubmed-meshheading:18555088-Male,
pubmed-meshheading:18555088-Middle Aged,
pubmed-meshheading:18555088-Mycophenolic Acid,
pubmed-meshheading:18555088-Prednisone,
pubmed-meshheading:18555088-Single-Blind Method,
pubmed-meshheading:18555088-Tablets, Enteric-Coated,
pubmed-meshheading:18555088-Treatment Failure,
pubmed-meshheading:18555088-Treatment Outcome
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pubmed:year |
2008
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pubmed:articleTitle |
Enteric-coated mycophenolate-sodium in heart transplantation: efficacy, safety, and pharmacokinetic compared with mycophenolate mofetil.
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pubmed:affiliation |
Department of Cardiac Transplantation, Deutsches Herzzentrum, Berlin, Germany. lehmkuhl@DHZB.de
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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