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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-8-28
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pubmed:abstractText |
1. The mechanism of action of flosequinan was investigated in ferret aortic smooth muscle by the simultaneous measurement of aequorin luminescence and isometric force. 2. The control calcium-force curve was obtained by plotting the calibrated aequorin luminescence against the force from potassium-depolarized muscles. Flosequinan relaxed potassium-depolarized muscles by causing parallel changes in [Ca2+]i and force with no shift in the control [Ca2+]i-force relationship. 3. The [Ca2+]i-force relationship in the presence of a maximally effective concentration of phenylephrine was significantly shifted to the left of that for the control, potassium-depolarized muscle. Flosequinan relaxed the phenylephrine-contracted muscle by causing a large decrease in force with only a minimal decrease in [Ca2+]i, resulting in an apparent rightward shift of the [Ca2+]i-force relationship, toward the control curve. 4. In comparison, sodium nitroprusside caused relaxation of either the potassium- or phenylephrine-induced contraction solely by a decrease in [Ca2+]i with no shift in either calcium-force relationship. 5. Milrinone caused no significant rightward shift of the calcium-force relationship during phenylephrine- or potassium-induced contractions, but when milrinone was added in the absence of vasoconstrictors, relaxation was obtained with no significant decrease in [Ca2+]i. 6. Flosequinan appears to differ in mechanism of action from both nitroprusside and milrinone. It relaxes depolarization-mediated contractions solely by decreasing [Ca2+]i but also appears to be capable of reversing the apparent calcium sensitizing action of phenylephrine.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-213432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-226548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-2408477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-2476620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-2551277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-2600829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-2758222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-2891533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3240769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3293682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3335525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3425738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3758157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3771537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3799427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-3970168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-6096534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-6747864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-6894576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1855126-7177776
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
974-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1855126-Aequorin,
pubmed-meshheading:1855126-Animals,
pubmed-meshheading:1855126-Aorta, Thoracic,
pubmed-meshheading:1855126-Calcium,
pubmed-meshheading:1855126-Ferrets,
pubmed-meshheading:1855126-Male,
pubmed-meshheading:1855126-Milrinone,
pubmed-meshheading:1855126-Muscle Contraction,
pubmed-meshheading:1855126-Nitroprusside,
pubmed-meshheading:1855126-Phenylephrine,
pubmed-meshheading:1855126-Potassium,
pubmed-meshheading:1855126-Pyridones,
pubmed-meshheading:1855126-Quinolines,
pubmed-meshheading:1855126-Vasodilator Agents
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pubmed:year |
1991
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pubmed:articleTitle |
Flosequinan, a vasodilator with a novel mechanism of action.
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pubmed:affiliation |
Charles Dana Research Institute, Harvard-Thorndike Laboratory, Department of Medicine, Harvard Medical School, Beth Israel Hospital, Boston, MA 02215.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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