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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-6-13
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pubmed:abstractText |
Folates provide one-carbon units for nucleotide synthesis and methylation reactions. A common polymorphism (677C-->T) in methylenetetrahydrofolate reductase (MTHFR) encodes an enzyme with reduced activity. Response to the antifolate methotrexate (MTX) may be modified in 677TT individuals because MTHFR converts nonmethylated folates, used for thymidine and purine synthesis, to 5-methyltetrahydrofolate, used in homocysteine remethylation to methionine. To study potential interactions between MTHFR activity and MTX, we examined the impact of decreased and increased MTHFR expression on MTX response in mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1744-6872
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pubmed:author |
pubmed-author:CeltikciBasakB,
pubmed-author:DengLiyuanL,
pubmed-author:FriedmanHana CHC,
pubmed-author:JamesS JillSJ,
pubmed-author:KrupenkoNatalia INI,
pubmed-author:KrupenkoSergey ASA,
pubmed-author:LawranceAndrea KAK,
pubmed-author:LeclercDanielD,
pubmed-author:MelnykStepanS,
pubmed-author:PetersonAlan CAC,
pubmed-author:RozenRimaR
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
577-89
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pubmed:meshHeading |
pubmed-meshheading:18551038-Animals,
pubmed-meshheading:18551038-Cells, Cultured,
pubmed-meshheading:18551038-Female,
pubmed-meshheading:18551038-Gene Expression,
pubmed-meshheading:18551038-Homocysteine,
pubmed-meshheading:18551038-Immunosuppression,
pubmed-meshheading:18551038-Immunosuppressive Agents,
pubmed-meshheading:18551038-Kidney Diseases,
pubmed-meshheading:18551038-Male,
pubmed-meshheading:18551038-Methotrexate,
pubmed-meshheading:18551038-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:18551038-Mice,
pubmed-meshheading:18551038-Mice, Inbred BALB C,
pubmed-meshheading:18551038-Mice, Inbred C57BL,
pubmed-meshheading:18551038-Mice, Knockout,
pubmed-meshheading:18551038-Models, Biological,
pubmed-meshheading:18551038-Polymorphism, Single Nucleotide
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pubmed:year |
2008
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pubmed:articleTitle |
Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice.
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pubmed:affiliation |
Departments of Human Genetics and Pediatrics, McGill University Health Centre, Montreal Children's Hospital Research Institute, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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