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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2008-7-2
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pubmed:abstractText |
Most nucleosomes are well-organized at the 5' ends of S. cerevisiae genes where "-1" and "+1" nucleosomes bracket a nucleosome-free promoter region (NFR). How nucleosomal organization is specified by the genome is less clear. Here we establish and inter-relate rules governing genomic nucleosome organization by sequencing DNA from more than one million immunopurified S. cerevisiae nucleosomes (displayed at http://atlas.bx.psu.edu/). Evidence is presented that the organization of nucleosomes throughout genes is largely a consequence of statistical packing principles. The genomic sequence specifies the location of the -1 and +1 nucleosomes. The +1 nucleosome forms a barrier against which nucleosomes are packed, resulting in uniform positioning, which decays at farther distances from the barrier. We present evidence for a novel 3' NFR that is present at >95% of all genes. 3' NFRs may be important for transcription termination and anti-sense initiation. We present a high-resolution genome-wide map of TFIIB locations that implicates 3' NFRs in gene looping.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-10409730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-10623509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-11058103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-11340174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-11838235,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-16522208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-16569694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-16860337,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-17873876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-17897965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-18059476,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-2031082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-2183026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-2798415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-3063825,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-3399412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-3806678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-3912515,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-7254354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-7781610,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-8683566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-8831784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-8996786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-9037027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-9115208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/18550805-9372930
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1088-9051
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1073-83
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:18550805-3' Untranslated Regions,
pubmed-meshheading:18550805-Chromosome Mapping,
pubmed-meshheading:18550805-Chromosomes, Fungal,
pubmed-meshheading:18550805-DNA, Fungal,
pubmed-meshheading:18550805-Genome, Fungal,
pubmed-meshheading:18550805-Models, Genetic,
pubmed-meshheading:18550805-Nucleosomes,
pubmed-meshheading:18550805-Promoter Regions, Genetic,
pubmed-meshheading:18550805-Saccharomyces cerevisiae
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pubmed:year |
2008
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