Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
24
pubmed:dateCreated
2008-6-13
pubmed:abstractText
The level of excitation in the brain is kept under control through inhibitory signals mainly exerted by GABA neurons. However, the molecular machinery that regulates the balance between excitation and inhibition (E/I) remains unclear. Candidate molecules implicated in this process are neuroligin (NL) adhesion molecules, which are differentially enriched at either excitatory or inhibitory contacts. In this study, we use transgenic mouse models expressing NL1 or NL2 to examine whether enhanced expression of specific NLs results in synaptic imbalance and altered neuronal excitability and animal behavior. Our analysis reveals several abnormalities selectively manifested in transgenic mice with enhanced expression of NL2 but not NL1. A small change in NL2 expression results in enlarged synaptic contact size and vesicle reserve pool in frontal cortex synapses and an overall reduction in the E/I ratio. The frequency of miniature inhibitory synaptic currents was also found to be increased in the frontal cortex of transgenic NL2 mice. These animals also manifested stereotyped jumping behavior, anxiety, impaired social interactions, and enhanced incidence of spike-wave discharges, as depicted by EEG analysis in freely moving animals. These findings may provide the neural basis for E/I imbalance and altered behavior associated with neurodevelopmental disorders.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
11
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6055-67
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:18550748-6-Cyano-7-nitroquinoxaline-2,3-dione, pubmed-meshheading:18550748-Analysis of Variance, pubmed-meshheading:18550748-Animals, pubmed-meshheading:18550748-Anxiety, pubmed-meshheading:18550748-Behavior, Animal, pubmed-meshheading:18550748-COS Cells, pubmed-meshheading:18550748-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:18550748-Cercopithecus aethiops, pubmed-meshheading:18550748-Electroencephalography, pubmed-meshheading:18550748-Inhibitory Postsynaptic Potentials, pubmed-meshheading:18550748-Interpersonal Relations, pubmed-meshheading:18550748-Membrane Proteins, pubmed-meshheading:18550748-Mice, pubmed-meshheading:18550748-Mice, Transgenic, pubmed-meshheading:18550748-Microscopy, Electron, Transmission, pubmed-meshheading:18550748-Nerve Tissue Proteins, pubmed-meshheading:18550748-Patch-Clamp Techniques, pubmed-meshheading:18550748-Picrotoxin, pubmed-meshheading:18550748-Prefrontal Cortex, pubmed-meshheading:18550748-Pyramidal Cells, pubmed-meshheading:18550748-Stereotyped Behavior, pubmed-meshheading:18550748-Synapses, pubmed-meshheading:18550748-Transfection, pubmed-meshheading:18550748-Vesicular Glutamate Transport Proteins
pubmed:year
2008
pubmed:articleTitle
Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression.
pubmed:affiliation
Department of Psychiatry, Brain Research Centre, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. rbruneau@interchange.ubc.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't